Insulin-like Growth Factor I (IGF-I)-stimulated Pancreatic β-Cell Growth Is Glucose-dependent SYNERGISTIC ACTIVATION OF INSULIN RECEPTOR SUBSTRATE-MEDIATED SIGNAL TRANSDUCTION PATHWAYS BY GLUCOSE AND IGF-I IN INS-1 CELLS*
Hügl S, White M, Rhodes C. Insulin-like Growth Factor I (IGF-I)-stimulated Pancreatic β-Cell Growth Is Glucose-dependent SYNERGISTIC ACTIVATION OF INSULIN RECEPTOR SUBSTRATE-MEDIATED SIGNAL TRANSDUCTION PATHWAYS BY GLUCOSE AND IGF-I IN INS-1 CELLS*. Journal Of Biological Chemistry 1998, 273: 17771-17779. PMID: 9651378, DOI: 10.1074/jbc.273.28.17771.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor IGrowth factor IBeta-cell proliferationINS-1 cell proliferationCell proliferationFactor IMM glucoseCombination of IGFPancreatic β-cell growthPancreatic beta-cell lineBeta-cell lineΒ-cell growthINS-1 cellsNM IGFBeta-cell mitogenesisCertain growth factorsSignaling mechanismSignal transduction pathwaysGlucose metabolismIGFCell proliferation rateGrowth factorIRS-2Transduction pathwaysGlucose concentrationPeripheral blood progenitor cell cycle kinetics following priming with pIXY321 in patients treated with the "ICE" regimen.
Murren JR, Gollerkeri A, Anderson S, Lutzker S, Del Prete S, Zelterman D, Garrison L, Smith B. Peripheral blood progenitor cell cycle kinetics following priming with pIXY321 in patients treated with the "ICE" regimen. The Yale Journal Of Biology And Medicine 1998, 71: 355-65. PMID: 10527363, PMCID: PMC2578930.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Non-Small-Cell LungCarcinoma, Small CellCell CycleEtoposideFemaleGranulocyte-Macrophage Colony-Stimulating FactorHematopoietic Stem CellsHumansIfosfamideInterleukin-3Lung NeoplasmsMaleMiddle AgedNeutropeniaRecombinant Fusion ProteinsSurvival RateTreatment OutcomeConceptsCell lung cancerPeripheral bloodLung cancerGrowth factorProgenitor cellsDay 1Non-small cell lung cancerSmall cell lung cancerCycle-specific chemotherapyCell cycle distributionHematopoietic growth factorsProgenitor cell cyclingHematologic recoveryPartial responseHematopoietic progenitor cellsCell cycle kineticsPreclinical dataCertain growth factorsSpecific chemotherapySubcutaneous injectionTransient fallCycling progenitor cellsReduced riskPatientsMarrow compartment
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