Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling
Zhang D, Ruan J, Peng S, Li J, Hu X, Zhang Y, Zhang T, Ge Y, Zhu Z, Xiao X, Zhu Y, Li X, Li T, Zhou L, Gao Q, Zheng G, Zhao B, Li X, Zhu Y, Wu J, Li W, Zhao J, Ge W, Xu T, Jia J. Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling. Nature Neuroscience 2024, 27: 232-248. PMID: 38168932, PMCID: PMC10849963, DOI: 10.1038/s41593-023-01515-0.Peer-Reviewed Original ResearchConceptsArteriolar smooth muscle cellsSmooth muscle cellsNeurovascular couplingPrevent Ca2+ overloadMuscle cellsNMDA receptor subunit 1Cerebral neurovascular couplingCa2+ overloadMouse cerebral cortexGluN1 subunitGlutamatergic axonsArteriolar constrictionSpreading depolarizationCerebral ischemiaCell-type specificityFunctional hyperemiaCerebral cortexPostsynaptic dendritesBrain atrophyCell junctionsArteriolesBrain functionAxonsBrainCells
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