Valve Interstitial Cells Act in a Pericyte Manner Promoting Angiogensis and Invasion by Valve Endothelial Cells
Arevalos C, Berg J, Nguyen J, Godfrey E, Iriondo C, Grande-Allen K. Valve Interstitial Cells Act in a Pericyte Manner Promoting Angiogensis and Invasion by Valve Endothelial Cells. Annals Of Biomedical Engineering 2016, 44: 2707-2723. PMID: 26905695, PMCID: PMC4983529, DOI: 10.1007/s10439-016-1567-9.Peer-Reviewed Original ResearchConceptsValvular interstitial cellsValve endothelial cellsROCK-dependent mannerInvasion of MatrigelVasculogenic networksCell organizationCo-CulturePhenotypic changesInvasive spheroidsCalcific aortic valve diseaseROCK activityControl cellsCell typesProgression of calcific aortic valve diseaseValve cellsCell culturesCell-activeEndothelial cellsPhenotypeCellsLong-term cultureSpheroid formationPericyte-like phenotypeBasal levelsInvasion
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