Neuromedin U receptor 1 deletion leads to impaired immunotherapy response and high malignancy in colorectal cancer
Zhou Y, Zhang X, Gao Y, Peng Y, Liu P, Chen Y, Guo C, Deng G, Ouyang Y, Zhang Y, Han Y, Cai C, Shen H, Gao L, Zeng S. Neuromedin U receptor 1 deletion leads to impaired immunotherapy response and high malignancy in colorectal cancer. IScience 2024, 27: 110318. PMID: 39055918, PMCID: PMC11269305, DOI: 10.1016/j.isci.2024.110318.Peer-Reviewed Original ResearchNeuromedin U receptor 1Colorectal cancerCytotoxic T-lymphocyte-associated protein 4CD8<sup>+</sup> T cell infiltrationCD8<sup>+</sup> T cellsLymphocyte activation gene-3Improve immunotherapy outcomesT cell infiltrationComprehensive multi-omics analysisPersonalized immunotherapy strategiesPatient-derived tissuesColorectal cancer cell linesColorectal cancer treatmentImmunotherapy outcomesImmune checkpointsImmunotherapy efficacyImmunotherapy strategiesImmunotherapy responsePrognostic significanceImmune infiltrationT cellsMulti-omics analysisCell infiltrationGenetic alterationsHigh malignancyEffect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Shewarega A, Santana J, Nam D, Berz A, Tefera J, Kahl V, Mishra S, Coman D, Duncan J, Roberts S, Wetter A, Madoff D, Chapiro J. Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma. Radiology 2024, 310: e232365. PMID: 38349244, PMCID: PMC10902598, DOI: 10.1148/radiol.232365.Peer-Reviewed Original ResearchConceptsT cell infiltrationCD8<sup>+</sup> T cellsMatrix metalloproteinase inhibitionT cellsHepatocellular carcinomaMatrix metalloproteinase inhibitorsMatrix metalloproteinasesResidual tumorCXCR3<sup>+</sup> CD8<sup>+</sup> T cellsCytotoxic CD8<sup>+</sup> T cell infiltrationIntratumoral CD8+ T cell infiltrationCD8+ T cell infiltrationCD8<sup>+</sup> T cell infiltrationMouse model of hepatocellular carcinomaEarly-stage hepatocellular carcinomaImage-guided tumor ablationUnpaired Student's <i>t</i> testModel of hepatocellular carcinomaFirst-line therapyMurine hepatocellular carcinomaT cell subsetsTumor-associated macrophagesMurine HCC modelLocal immune responseFemale BALB/c mice
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