2021
Whole-exome Sequencing in Penile Squamous Cell Carcinoma Uncovers Novel Prognostic Categorization and Drug Targets Similar to Head and Neck Squamous Cell CarcinomaClinical Implications of WES in Penile Squamous Carcinoma
Chahoud J, Gleber-Netto FO, McCormick BZ, Rao P, Lu X, Guo M, Morgan MB, Chu RA, Martinez-Ferrer M, Eterovic AK, Pickering CR, Pettaway CA. Whole-exome Sequencing in Penile Squamous Cell Carcinoma Uncovers Novel Prognostic Categorization and Drug Targets Similar to Head and Neck Squamous Cell CarcinomaClinical Implications of WES in Penile Squamous Carcinoma. Clinical Cancer Research 2021, 27: 2560-2570. PMID: 33441293, DOI: 10.1158/1078-0432.ccr-20-4004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCase-Control StudiesComputational BiologyDisease ManagementDisease SusceptibilityExome SequencingHumansMaleMiddle AgedMolecular Targeted TherapyMutationNeoplasm GradingNeoplasm StagingPenile NeoplasmsPrognosisSquamous Cell Carcinoma of Head and NeckConceptsPenile squamous cell carcinomaSquamous cell carcinomaCell carcinomaHuman papilloma virus testingNeck squamous cell carcinomaNotch pathway alterationsMutation signaturesTumor mutation burdenWorse overall survivalLimited treatment optionsWhole-exome sequencing analysisPenile squamous carcinomaPotential clinical implicationsMutational signaturesDefective DNA mismatch repairCancer Genome Atlas studyWhole-exome sequencingNovel druggable targetsDistinct mutational signaturesNormal penile tissuesOverall survivalWorse survivalHigh TMBSquamous carcinomaPenile tissue
2018
Gastric Carcinomas With Lymphoid Stroma
Hissong E, Ramrattan G, Zhang P, Zhou X, Young G, Klimstra D, Shia J, Fernandes H, Yantiss R. Gastric Carcinomas With Lymphoid Stroma. The American Journal Of Surgical Pathology 2018, 42: 453-462. PMID: 29438172, DOI: 10.1097/pas.0000000000001018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBiopsyCarcinomaDNA Mismatch RepairFemaleGenetic Predisposition to DiseaseHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumansImmunohistochemistryIn Situ HybridizationLymphocytes, Tumor-InfiltratingMaleMicrosatellite InstabilityMiddle AgedMutationPhenotypeRetrospective StudiesRNA, ViralStomach NeoplasmsStromal CellsConceptsPD-L1 expressionEpstein-Barr virusLymphoid stromaGastric carcinomaPD-L1Frequent PD-L1 expressionSusceptible to checkpoint inhibitorsConventional gastric cancerTumor-infiltrating lymphocytesTumor mutational burdenEBV-encoded RNASubgroup of tumorsComprehensive Cancer PanelSpectrum of molecular changesCancer Genome Atlas studyEvaluated molecular alterationsIn situ hybridizationMismatch repair statusCheckpoint inhibitorsCancer Genome Atlas datasetHER2 amplificationInfiltrating lymphocytesGlandular differentiationKRAS alterationsTP53 variants
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