2023
Technology-enhanced acceleration of germline evaluation for therapy (TARGET): Results of a randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing.
Giri V, Keith S, Cheng H, Leader A, Gross L, Sanchez Nolasco T, Byrne N, Hartman R, Brown L, Pieczonka C, Gomella L, Kelly W, Lallas C, Handley N, Mille P, Mark J, Brown G, Chopra S, McClellan A, Loeb S. Technology-enhanced acceleration of germline evaluation for therapy (TARGET): Results of a randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing. Journal Of Clinical Oncology 2023, 41: 10598-10598. DOI: 10.1200/jco.2023.41.16_suppl.10598.Peer-Reviewed Original ResearchDecisional conflictGenetic testingPre-test genetic counselingGermline testingGenetic counselingProstate cancerRandomized non-inferiority trialHereditary cancer risk assessmentGermline genetic testingClinical trial eligibilityNon-inferiority trialProstate Cancer FoundationProstate cancer managementCancer genetic testingDecision Conflict ScaleCancer risk assessmentGermline evaluationTrial eligibilityPrimary endpointMean ageStudy protocolCancer managementGenetics educationAnalysis of covarianceCancer Foundation
2022
Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing
Loeb S, Cheng H, Leader A, Gross L, Nolasco T, Byrne N, Wise D, Hollifield L, Brown L, Slater E, Pieczonka C, Gomella L, Kelly W, Trabulsi E, Handley N, Lallas C, Chandrasekar T, Mille P, Mann M, Mark J, Brown G, Chopra S, Wasserman J, Phillips J, Somers P, Giri V. Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing. Contemporary Clinical Trials 2022, 119: 106821. PMID: 35710085, DOI: 10.1016/j.cct.2022.106821.Peer-Reviewed Original ResearchConceptsKey patient-reported outcomesGermline testingPatient-reported outcomesProstate cancerGenetic counselingCollaborative care strategiesProstate cancer careTwo-armed randomizedProstate Cancer FoundationEducation/counselingGermline evaluationGOV IDENTIFIERPrimary outcomeSecondary outcomesStudy armsTarget enrollmentAshkenazi Jewish ancestryCancer careFamily historyTumor featuresCancer FoundationCare strategiesDecisional conflictUS sitesPractice settings
2021
Prostate cancer research in the 21st century; report from the 2021 Coffey‐Holden prostate cancer academy meeting
Miyahira A, Zarif J, Coombs C, Flavell R, Russo J, Zaidi S, Zhao D, Zhao S, Pienta K, Soule H. Prostate cancer research in the 21st century; report from the 2021 Coffey‐Holden prostate cancer academy meeting. The Prostate 2021, 82: 169-181. PMID: 34734426, PMCID: PMC8688282, DOI: 10.1002/pros.24262.Peer-Reviewed Original ResearchConceptsCoffey-Holden Prostate Cancer Academy MeetingCoffey-Holden Prostate Cancer AcademyProstate cancer researchProstate cancerMetastatic castration resistant prostate cancerCastration resistant prostate cancerResistant prostate cancerProstate cancer biologyProstate Cancer FoundationCancer researchAntitumor immunityCancer immunotherapyClonal hematopoiesisMediators of plasticityTumor microenvironmentTargeted therapyProstateCell plasticityCancer FoundationCancer biologyCancerSignaling pathwayCancer genomesSignaling biologyAcademy Meeting
2009
Prostate cancer clinical trials consortium: A multicenter mechanism for the rapid design, development, and implementation of early phase clinical trials
Vinson J, Mathew P, Beer T, Carducci M, Oh W, Small E, Wilding G, Higano C, Hussain M, Scher H. Prostate cancer clinical trials consortium: A multicenter mechanism for the rapid design, development, and implementation of early phase clinical trials. Journal Of Clinical Oncology 2009, 27: e16065-e16065. DOI: 10.1200/jco.2009.27.15_suppl.e16065.Peer-Reviewed Original ResearchProstate Cancer Clinical Trials ConsortiumProstate Cancer FoundationProstate cancerClinical trialsMulticenter studyMemorial Sloan-Kettering Cancer CenterEarly phase clinical trialsPhases of clinical testingPhase clinical trialsClinical Trials ConsortiumCancer Research CenterMulticenter trialProstateMulticenterCancer CenterEarly-phaseCancer FoundationClinical testingCancerPatientsTrial designTrialsOperative procedureEarly phaseLead investigators
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