2014
Multivalency as a Key Factor for High Activity of Selective Supported Organocatalysts for the Baylis–Hillman Reaction
Goren K, Karabline‐Kuks J, Shiloni Y, Barak‐Kulbak E, Miller SJ, Portnoy M. Multivalency as a Key Factor for High Activity of Selective Supported Organocatalysts for the Baylis–Hillman Reaction. Chemistry - A European Journal 2014, 21: 1191-1197. PMID: 25376519, DOI: 10.1002/chem.201404560.Peer-Reviewed Original ResearchConceptsNew carbon-carbon bondsCarbon-carbon bondsRate-determining proton transferThird generation analoguesMethyl vinyl ketoneBaylis–Hillman reactionAnalogous catalystsDendritic catalystsSupported OrganocatalystsImidazole unitsDendritic effectReaction solventIntermediate adductModel reactionProton transferImidazole moietyActive substratesVinyl ketoneCatalystP-nitrobenzaldehydeReaction yieldMultivalent architectureHigh activityContent of waterHigher generations
1996
Chapter 31. Solid-Phase Synthesis: Applications to Combinatorial Libraries
Choong I, Ellman J. Chapter 31. Solid-Phase Synthesis: Applications to Combinatorial Libraries. Annual Reports In Medicinal Chemistry 1996, 31: 309-318. DOI: 10.1016/s0065-7743(08)60470-4.Peer-Reviewed Original ResearchSolid-phase synthesisSolid supportFunctional group titrationCarbon-heteroatom bondsCompound structureCarbon-carbon bondsNew support materialDifferent analytical techniquesSmall molecule librariesSolid-phase reactionPrivileged structuresDiscrete compoundsLibrary synthesisMulticomponent reactionPhase synthesisParallel synthesisReaction conditionsBiological evaluationSynthesis sequenceFunctional groupsSupport materialLead optimizationCombinatorial librariesAnalytical techniquesLibrary design
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