2022
SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP
Chau JE, Vish KJ, Boggon TJ, Stiegler AL. SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP. Nature Communications 2022, 13: 4788. PMID: 35970859, PMCID: PMC9378701, DOI: 10.1038/s41467-022-32541-4.Peer-Reviewed Original ResearchConceptsRhoGAP activitySH3 domainCatalytic arginine fingerIntrinsic GTPase activityRho family GTPasesLiver cancer 1GAP proteinsRhoGAP proteinArginine fingerCo-crystal structureRas GTPasesGAP activityRho proteinsCellular processesGTPase activityMolecular basisKey regulatorTumor suppressorP120RasGAPCell migrationProteinGTPasesRhoGAPCancer 1Binding sites
2003
Production, purification, and functional analysis of recombinant human and mouse 17β-hydroxysteroid dehydrogenase type 7
Törn S, Nokelainen P, Kurkela R, Pulkka A, Menjivar M, Ghosh S, Coca-Prados M, Peltoketo H, Isomaa V, Vihko P. Production, purification, and functional analysis of recombinant human and mouse 17β-hydroxysteroid dehydrogenase type 7. Biochemical And Biophysical Research Communications 2003, 305: 37-45. PMID: 12732193, DOI: 10.1016/s0006-291x(03)00694-6.Peer-Reviewed Original ResearchConceptsPeripheral tissuesType 7Primary open-angle glaucomaEarly-onset prostate cancerOpen-angle glaucomaSex steroid hormonesIntracrine regulatorAdrenal glandProstate cancerEstrogenic milieuPotent androgenInactive metabolitesEstrogenic metabolitesSteroid metabolismPotent estrogenSteroid hormonesCancer 1DihydrotestosteroneRecombinant humanTissue distributionHormoneTissueHuman tissuesPresent studyMetabolic role
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