2025
Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Yang K, Kim K, Ryu T, Shim Y, Kim H, Choi S, Kim M, Chung K, Lee E, Lee K, Jeon J, Kim P, Kim Y, Ku T, Jeong H, Nam K, Lim G, Choi D, Kim S, Eun H, Kim W, Jeong W. Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. Nature Communications 2025, 16: 5546. PMID: 40595616, PMCID: PMC12216207, DOI: 10.1038/s41467-025-60820-3.Peer-Reviewed Original ResearchConceptsVesicular glutamate transporter 3Alcohol-related steatohepatitisKupffer cellsIntracellular Ca2+ levelsMetabotropic glutamate receptor 5Chronic alcohol intakeBinge drinkingImmune cell activationGlutamate receptor 5Analysis of patient samplesCa2+ levelsHepatic amino acid metabolismNADPH oxidase 2Plasma glutamate concentrationExocytosis of glutamateAlcohol intakeReceptor 5Male miceAryl hydrocarbon receptorAmino acid metabolismHepatic inflammationCell activationPerivenous hepatocytesGlutamate secretionPatient samples
1997
Reconstitution of Calcium-Regulated Parathyroid Hormone Secretion from Streptolysin-O-Permeabilized Parathyroid Cells by Guanosine 5′-O-(Thio)Triphosphate*
Matovcik L, Rhee S, Schaefer J, Kinder B. Reconstitution of Calcium-Regulated Parathyroid Hormone Secretion from Streptolysin-O-Permeabilized Parathyroid Cells by Guanosine 5′-O-(Thio)Triphosphate*. Endocrinology 1997, 138: 1170-1179. DOI: 10.1210/en.138.3.1170.Peer-Reviewed Original ResearchIntracellular Ca2+ levelsPTH secretionParathyroid cellsCa2+ levelsPhysiological intracellular Ca2+ levelsHormone secretionRate of PTH secretionCalcium/calmodulin-dependent protein kinase IIIncreased PTH secretionInhibit PTH secretionParathyroid hormone secretionExtracellular Ca2+Regulation of hormone secretionCa2+ concentrationDose-dependent mannerProtein kinase IICa2+-dependent regulationAmbient Ca2+ concentrationStreptolysin OIn vitro model systemPTH releaseIntracellular Ca2SLO-permeabilized cellsKinase IISecretion
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