ProDualNet: dual-target protein sequence design method based on protein language model and structure model
Cheng L, Wei T, Cui X, Chen H, Yu Z. ProDualNet: dual-target protein sequence design method based on protein language model and structure model. Briefings In Bioinformatics 2025, 26: bbaf391. PMID: 40856523, PMCID: PMC12378908, DOI: 10.1093/bib/bbaf391.Peer-Reviewed Original ResearchConceptsSequence-structure informationProtein language modelsAllosteric bindingIn silico evaluationSequence design methodProtein sequencesProtein designBinding proteinBiological processesMulti-target strategyProteinHeterogeneous graph networkMultiple receptorsMultiple test setsLanguage modelGraph networkBindingExperimental structuresSingle receptorDesign networksReceptorsTest setTherapeutic potential
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