Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics
Steger M, Nishiguchi G, Wu Q, Schwalb B, Shashikadze B, McGowan K, Actis M, Aggarwal A, Shi Z, Price J, Mayasundari A, Yang L, Bednarz A, Machata S, Graef T, Bartoschek D, Demichev V, Ohmayer U, Yang J, Daub H, Rankovic Z. Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics. Nature Communications 2025, 16: 7773. PMID: 40835825, PMCID: PMC12368047, DOI: 10.1038/s41467-025-62829-0.Peer-Reviewed Original ResearchConceptsMolecular glue degradersHigh-throughput proteomic platformsData-independent acquisition mass spectrometryDIA-MSMass spectrometryHigh-throughput proteomicsSmall moleculesDrug discoveryGlue degradersRelationship analysisLabel-freeScreening approachTarget proteinsPhenylNovel degradersImideDegradation of target proteinsProteomics platformUbiquitin-proteasome systemNeosubstratesLigandDegradationSpectrometryMoleculesProteome-wide screening approach
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