Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles.
Liu Y, Wang X, Krishnan N, Hsiao T, Ji Y, Kaneko K, Teneche M, Adams P, Zuniga E, Kaech S, Zhang L, Feng G. Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles. Hepatology 2025 PMID: 40928035, DOI: 10.1097/hep.0000000000001514.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsAPD-L1Liver tumorsLipid nanoparticlesTumor-suppressive effectsSingle doseCD8+ T cell infiltrationAnti-PD-L1 antibodyLiver cancerAssociated with several adverse effectsAnti-PD-L1T cell infiltrationMetastatic liver tumorsMechanism-based therapeutic agentsHepatic immune microenvironmentType I Interferon SignalingLiver tumor modelLiver tumor progressionLiver-targeting strategiesSevere adverse effectsI interferon signalingEfficacious monotherapyCheckpoint inhibitorsAntitumor immunityAntitumor response
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