WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation
Wu M, Sadhu R, Meyer K, Tang Z, Marchando P, Woolfson D, Gov N, Weiner O. WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation. Journal Of Cell Biology 2025, 224: e202410098. PMID: 40668190, PMCID: PMC12266138, DOI: 10.1083/jcb.202410098.Peer-Reviewed Original ResearchConceptsNucleation-promoting factorsNegative membrane curvatureLamellipodia formationActin nucleation-promoting factorMembrane curvatureIn vivo biochemical approachesSheet-like lamellipodiaActin-based protrusionsCell morphogenesisMembrane associationCell protrusionsBiochemical approachesUpstream activatorPlasma membraneLamellipodiaProtein arraysMechanistic basesLinear organizationWave complexesComplex patternsABI2WAVE2ActinLinear arrayMorphogenesis
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