Trends and outcomes of tenecteplase and alteplase usage for ischemic stroke in the United States
Anadani M, Hamoud L, Chase B, Wang C, Kassam A, Akanda M, de Havenon A, Kassab S, Gory B, Kashiouris M, Jumaa M. Trends and outcomes of tenecteplase and alteplase usage for ischemic stroke in the United States. Clinical Neurology And Neurosurgery 2025, 258: 109150. PMID: 40967056, DOI: 10.1016/j.clineuro.2025.109150.Peer-Reviewed Original ResearchIn-Hospital MortalityIntracranial hemorrhageHome dischargeHigher oddsAcute ischemic strokeTNK groupIschemic strokeHigher likelihood of home dischargeOdds of intracranial hemorrhageSensitivity analysis restricted to patientsRate of intracranial hemorrhageStroke patients treated with intravenous thrombolysisOdds of in-hospital mortalityAssociated with home dischargeIschemic stroke patients treated with intravenous thrombolysisPatients treated with intravenous thrombolysisAssociated with higher oddsAnalysis restricted to patientsLikelihood of home dischargeRate of home dischargeTreated with alteplaseHigher likelihoodRestricted to patientsNo significant associationEndovascular therapy
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