Enzymological Analysis of Mutant Protein Kinase Cγ Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+ Homeostasis*
Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, Saito N. Enzymological Analysis of Mutant Protein Kinase Cγ Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+ Homeostasis*. Journal Of Biological Chemistry 2008, 283: 19854-19863. PMID: 18499672, DOI: 10.1074/jbc.m801492200.Peer-Reviewed Original ResearchConceptsCa2+-mediated signalingDomain mutantsMembrane residence timeEnzymological analysisIn vitro kinase assaySpinocerebellar ataxia type 14Total internal reflection fluorescence microscopyAutosomal dominant neurodegenerative diseaseDominant neurodegenerative diseaseSustained Ca2Bind diacylglycerolSingle molecule observationMembrane associationResponse to muscarinic receptor stimulationEnzymological propertiesKinase assayMutantsKinase activityC1 domainReceptor ligationPlasma membraneType 14Muscarinic receptor stimulationMediated signalingWild-type
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply