Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis
Xiao T, Langston P, Muñoz-Rojas A, Jayewickreme T, Lazar M, Benoist C, Mathis D. Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis. Science Immunology 2022, 7: eabl7641. PMID: 36179011, PMCID: PMC9769829, DOI: 10.1126/sciimmunol.abl7641.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueBmal1 deficiencyVisceral adipose tissue inflammationWeeks of high-fat diet feedingRegulatory T cellsAdipose tissueCircadian clock expressionTranscriptomic signaturesCore clock componentsLoss of fitnessHigh-fat diet feedingCore clock genesSuppression of lipolysisDiurnal rhythmNonlymphoid organsT cellsAdipose tissue lipolysisDiurnal regulationCircadian programTissue homeostasisAdipocyte lipolysisConstitutive activationDiet feedingUp-regulatedMetabolic state
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