Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage
Reyes-Esteves S, Nong J, Glassman P, Omo-Lamai S, Ohashi S, Myerson J, Zamora M, Ma X, Kasner S, Sansing L, Muzykantov V, Marcos-Contreras O, Brenner J. Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage. Journal Of Controlled Release 2023, 356: 185-195. PMID: 36868517, PMCID: PMC10519578, DOI: 10.1016/j.jconrel.2023.02.037.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageVascular leakBrain accumulationEarly time pointsBrain endotheliumClinical ICHTime pointsExperimental intracerebral hemorrhageSpecific drug therapyBlood-brain barrierFatal strokeICH inductionIntrastriatal injectionICH onsetDrug therapyHematoma expansionImmune attackBrain deliveryCommon causeVascular endotheliumBlood leakDrug accumulationIntravenous deliveryBrain regionsHemorrhage
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