2019
Human Ovarian Cancer Tumor Formation in Severe Combined Immunodeficient (SCID) Pigs
Boettcher AN, Kiupel M, Adur MK, Cocco E, Santin AD, Bellone S, Charley SE, Blanco-Fernandez B, Risinger JI, Ross JW, Tuggle CK, Shapiro EM. Human Ovarian Cancer Tumor Formation in Severe Combined Immunodeficient (SCID) Pigs. Frontiers In Oncology 2019, 9: 9. PMID: 30723704, PMCID: PMC6349777, DOI: 10.3389/fonc.2019.00009.Peer-Reviewed Original ResearchPreclinical animal modelsSCID pigsOvarian carcinomaAnimal modelsEar tissueLate-stage diseaseLethal gynecologic malignancyOvarian cancer researchImmunodeficient pigsGynecologic malignanciesCarcinoma cell linesImmunohistochemical phenotypeCytokeratin 7Ovarian cancerXenotransplantation modelNeck musclesOrthotopic modelTumor massOvCa cellsPapillary carcinoma cell lineCarcinomaControl pigsClaudin-4Claudin-3TumorsA highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S. A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies. Nature Communications 2019, 10: 366. PMID: 30664659, PMCID: PMC6341122, DOI: 10.1038/s41467-018-08166-x.Peer-Reviewed Original ResearchConceptsPatient-derived xenograftsMyelodysplastic syndromeXenotransplantation modelDysplastic morphologyImmunodeficient murine hostsPre-clinical studiesMDS stem cellsMDS subtypesComprehensive preclinical studiesPreclinical studiesTherapeutic efficacyMurine hostSerial transplantationDrug mechanismsMDS researchStem cell propagationStem cellsDifferentiation potentialHematopoietic stem cell nicheGenetic complexityNovel avenuesStem cell nicheCell propagationDisease representationsImmunodeficient
2007
FK778 in Experimental Xenotransplantation: A Detailed Analysis of Drug Efficacy
Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier M, Robbins R, Reichenspurner H. FK778 in Experimental Xenotransplantation: A Detailed Analysis of Drug Efficacy. The Journal Of Heart And Lung Transplantation 2007, 26: 70-77. PMID: 17234520, DOI: 10.1016/j.healun.2006.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAlkynesAnimalsAntibodies, Anti-IdiotypicAorta, AbdominalCricetinaeDisease Models, AnimalEndothelium, VascularFlow CytometryGraft RejectionHumansImmunoglobulin GImmunoglobulin MInterleukin-2 Receptor alpha SubunitIsoxazolesMaleNitrilesRatsRats, Inbred BNRats, Inbred LewT-LymphocytesTransplantation, HeterologousTreatment OutcomeConceptsXenograft rejectionCombination regimensHyperacute rejectionMyocyte necrosisAnalysis of drug efficacyEfficacy of FK778Model of hyperacute rejectionXenoantibody productionMonotherapy groupImmunosuppressive treatmentCD25 expressionFK778TacrolimusUntreated ratsXenotransplantation modelAortic xenograftsDose-dependentlyComplement depositionExperimental xenotransplantationSirolimusHumoral responseDrug efficacyXenograft infiltrationXenoreactive IgMRegimens
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