2025
Cortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia
Jiang X, Gou M, Yin Y, Chen W, Li Y, Chen S, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Wang J, Li H, Yu T, Wang Z, Zhang P, Huang J, Tian L, Kochunov P, Li C, Hong L, Tan Y. Cortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia. Psychoneuroendocrinology 2025, 179: 107501. PMID: 40479922, DOI: 10.1016/j.psyneuen.2025.107501.Peer-Reviewed Original ResearchCortisol response patternsDuration of illnessDiffusion tensor imagingCortisol levelsWM integrityPositive and Negative Syndrome ScaleResponse to acute stress exposureHC groupPaced Auditory Serial Addition TaskResponse patternsNegative Syndrome ScaleFirst-episode schizophreniaBiomarkers of schizophreniaAcute stress exposureWhite matter integrityWM microstructural integrityWM tract integritySalivary cortisol levelsSyndrome ScaleChronic schizophreniaClinical psychopathologyCortisol reactivitySchizophrenia pathogenesisWhite matterBrain regions
2024
The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure
Zhang F, Li Y, Chen R, Shen P, Wang X, Meng H, Du J, Yang G, Liu B, Niu Q, Zhang H, Tan Y. The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure. ENeuro 2024, 11: eneuro.0128-24.2024. PMID: 39142823, PMCID: PMC11360986, DOI: 10.1523/eneuro.0128-24.2024.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentFunctional connectivityCognitive impairmentNeural mechanismsRight inferior frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingInferior frontal gyrusRight anterior cingulateRight temporal poleFunctional connectivity differencesWhite matter integrityRight sagittal stratumFractional anisotropy valuesAnterior cingulateFrontal gyrusDiffusion tensor imagingMontreal Cognitive AssessmentTemporal poleWhite matterWM integrityPlasma Al concentrationParacingulate gyriCognitive AssessmentSagittal stratumPreliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5
2023
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study
Kara F, Tosakulwong N, Lesnick T, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling N, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.064187.Peer-Reviewed Original ResearchKronos Early Estrogen Prevention StudyDiastolic blood pressureGreater WMH volumeWM injuryWMH volumeWM hyperintensitiesPostmenopausal womenBlood pressureMenopausal transitionRisk factorsHigher white matter hyperintensity volumeWaist/hip ratioWhite matter hyperintensity volumeHormone therapy trialsCVD risk factorsMenopausal hormone therapyWM integrityWhite matter injuryAssociation of BPBetter cardiovascular healthEarly postmenopausal stageLow-density lipoproteinContinuation studyTotal intracranial volumeBaseline SBP
2015
Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia
Wright S, Hong L, Winkler A, Chiappelli J, Nugent K, Muellerklein F, Du X, Rowland L, Wang D, Kochunov P. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia. Human Brain Mapping 2015, 36: 3793-3804. PMID: 26108347, PMCID: PMC4714540, DOI: 10.1002/hbm.22878.Peer-Reviewed Original ResearchConceptsWM integrityDiffusion tensor imagingArterial spin labelingPatient-control differencesPS deficitsReduced WM integrityPerfusion shiftCerebral information processingLower WM integrityCerebral WMNeurophysiological alterationsInformation processing speedSchizophrenia patientsGray matterCognitive deficitsTensor imagingBlood perfusionSchizophreniaDeficitsFurther examinationSpin labelingProcessing speedPatientsCohortPerfusion
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