Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development
Yuan T, Wang Y, Jin Y, Yang H, Xu S, Zhang H, Chen Q, Li N, Ma X, Song H, Peng C, Geng Z, Dong J, Duan G, Sun Q, Yang Y, Yang F, Huang Z. Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. ELife 2024, 12: rp87559. PMID: 38289338, PMCID: PMC10942592, DOI: 10.7554/elife.87559.Peer-Reviewed Original ResearchConceptsKCNT1-related epilepsyVoltage-gated sodium channel Na<sub>v</sub>1.6Treated patientsViral expressionTherapeutic strategiesBlockadeSodium influxHomozygous knockoutQuinidineEpilepsyDrug discovery effortsMutant variantsNav1.6KCNT1
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