2024
30 years of HIV therapy: Current and future antiviral drug targets
Nuwagaba J, Li J, Ngo B, Sutton R. 30 years of HIV therapy: Current and future antiviral drug targets. Virology 2024, 603: 110362. PMID: 39705895, PMCID: PMC11788039, DOI: 10.1016/j.virol.2024.110362.Peer-Reviewed Original ResearchConceptsHIV-1HIV-1 cureCCR5 co-receptorInhibit HIV-1 replicationHIV-1 RNAHIV-1 replicationTarget reverse transcriptaseHIV-1 TatViral long terminal repeatFunctional cureAntiretroviral therapyHIV therapyNovel therapiesDrug resistanceLong terminal repeatDrug interactionsTherapeutic strategiesTherapeutic gapLifelong adherenceCo-receptorViral entryTherapyHAARTReverse transcriptaseDrug
1993
Blockade of human immunodeficiency virus type 1 production in CD4+ T cells by an intracellular CD4 expressed under control of the viral long terminal repeat.
Buonocore L, Rose J. Blockade of human immunodeficiency virus type 1 production in CD4+ T cells by an intracellular CD4 expressed under control of the viral long terminal repeat. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 2695-2699. PMID: 8464877, PMCID: PMC46162, DOI: 10.1073/pnas.90.7.2695.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 productionHIV-1 infectionInfectious HIV-1HIV envelope proteinHuman T cell lineSoluble CD4 proteinT cell linesT cellsHIV-1Viral spreadSyncytium formationInfected cellsViral long terminal repeatCD4CD4 proteinEnvelope proteinIntracellular CD4Intracellular trapsGene therapyLong terminal repeatRetroviral vectorsCellsCell surfaceHIVBlockade
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