2015
BMP signaling and microtubule organization regulate synaptic strength
Ball R, Peled E, Guerrero G, Isacoff E. BMP signaling and microtubule organization regulate synaptic strength. Neuroscience 2015, 291: 155-166. PMID: 25681521, PMCID: PMC4369397, DOI: 10.1016/j.neuroscience.2015.01.069.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAnimalsAnimals, Genetically ModifiedBone Morphogenetic ProteinsCalciumDNA-Binding ProteinsDrosophilaDrosophila ProteinsFemaleFluorescent DyesImmunohistochemistryMicrotubule-Associated ProteinsMicrotubulesNeuromuscular JunctionPatch-Clamp TechniquesPresynaptic TerminalsReceptors, Cell SurfaceSynaptic TransmissionTranscription FactorsConceptsBone morphogenetic proteinMicrotubule organizationGlutamatergic Drosophila neuromuscular junctionDrosophila neuromuscular junctionLarval neuromuscular junctionDistal boutonsNeuromuscular junctionBMP pathwaySynaptic transmissionMorphogenetic proteinsSynaptic growthMolecular pathwaysSynaptic strengthMicrotubule systemHomeostatic regulationPathwayMicrotubulesSpastin mutationsPostsynaptic partnersMutationsTransmission strengthSelective mannerMuscle fibersProteinRegulation
2013
Regulation of systemic iron homeostasis
Finberg KE. Regulation of systemic iron homeostasis. Current Opinion In Hematology 2013, 20: 208-214. PMID: 23426198, DOI: 10.1097/moh.0b013e32835f5a47.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic iron balanceMolecular mechanismsBone morphogenetic protein (BMP) type IHypoxia-inducible factor (HIF) pathwayInducible factor pathwayProtein type IHepcidin synthesisIron balanceBMP pathwayTransferrin receptor 2Systemic iron homeostasisCapacity of erythropoietinIron homeostasisComplex biologyNonredundant roleTissue culture systemHepcidin levelsInfectious stimuliIron storesFactor pathwayDietary ironErythropoietic activityReceptor 2PathwayAnimal models
2012
CREBZF, a novel Smad8-binding protein
Lee J, Lee G, Kwon S, Jeong J, Ha Y, Kim W, Kim I. CREBZF, a novel Smad8-binding protein. Molecular And Cellular Biochemistry 2012, 368: 147-153. PMID: 22707059, DOI: 10.1007/s11010-012-1353-4.Peer-Reviewed Original ResearchConceptsSmads 1Novel SmadTranscription factorsBMP-6Basic region-leucine zipper (bZIP) transcription factorsBone morphogenetic protein (BMP) pathwayRegulation of SmadTwo-hybrid screeningModulation of BMPBMP response elementZipper transcription factorTGF-β signal pathwayR-SmadsReceptor SmadsBMP pathwaySecondary messengersPromoter activityLigand bindingProtein pathwayResponse elementProstate cancer cell linesCell growth inhibitionHuman prostate cancer cell linesSmadSignal pathway
2010
Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort
Fernández-Rozadilla C, de Castro L, Clofent J, Brea-Fernández A, Bessa X, Abulí A, Andreu M, Jover R, Xicola R, Llor X, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C. Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort. PLOS ONE 2010, 5: e12673. PMID: 20844743, PMCID: PMC2936577, DOI: 10.1371/journal.pone.0012673.Peer-Reviewed Original ResearchConceptsBMP pathwayLow-penetrance variantsNew susceptibility lociNew risk variantsCandidate gene studiesCarcinogenesis-related pathwaysPathway-based studiesRegulatory SNPsSingle nucleotide polymorphismsAssociation studiesCase-control association studySusceptibility lociGenesSusceptibility variantsRisk variantsNucleotide polymorphismsComplex diseasesSigns of associationPolygenic modelPathwayWntHaplotypic analysisGenetic susceptibilityNatural strategyVariantsRobust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation Propensity
Kim DS, Lee JS, Leem JW, Huh YJ, Kim JY, Kim HS, Park IH, Daley GQ, Hwang DY, Kim DW. Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation Propensity. Stem Cell Reviews And Reports 2010, 6: 270-281. PMID: 20376579, DOI: 10.1007/s12015-010-9138-1.Peer-Reviewed Original ResearchConceptsDifferentiation propensityStem cell linesCell lineagesNeural differentiationHuman embryonic stem cell linesEmbryonic stem cell linesCell typesActivin/NodalHuman pluripotent stem cell linesDesirable cell typesSpecific cell typesCell linesModulation of intracellularPluripotent stem cellsPluripotent stem cell lineBMP pathwaySpecific lineagesIPS cellsUndifferentiated cellsLineagesDifferentiation potentialHuman ESStem cellsNeural cellsDifferentiation
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