Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy
Mastorakos P, da Silva A, Chisholm J, Song E, Choi W, Boyle M, Morales M, Hanes J, Suk J. Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 8720-8725. PMID: 26124127, PMCID: PMC4507234, DOI: 10.1073/pnas.1502281112.Peer-Reviewed Original ResearchConceptsHigh-level transgene expressionGene delivery systemsDNA nanoparticlesTransgene expressionNanoparticle-based gene delivery systemGene therapyDelivery systemLung gene therapyRobust transgene expressionTherapeutic genesTransfection efficiencyColloidal stabilityNanoparticlesBiological barriersTunable platformPhysiological fluidsBiodegradable polymersDense coronaConventional therapeuticsMucus barrierPolyethylene glycolMucus gel layerTreatment of diseasesSignificant hurdlePBAE
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