Respiratory Syncytial Virus Stimulation of Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor
Lee C, Yoon H, Zhu Z, Link H, Wang Z, Gwaltney J, Landry M, Elias J. Respiratory Syncytial Virus Stimulation of Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor. American Journal Of Respiratory Cell And Molecular Biology 2000, 23: 662-669. PMID: 11062145, DOI: 10.1165/ajrcmb.23.5.4188.Peer-Reviewed Original ResearchConceptsVascular endothelial cell growth factorVEGF/VPFRespiratory syncytial virus stimulationRespiratory syncytial virusAcid isoformNormal human bronchial epithelial cellsEndothelial cell growth factorHuman bronchial epithelial cellsUnstimulated A549 cellsVascular permeability factorBronchial epithelial cellsCell growth factorVEGF messenger RNARSV infectionSyncytial virusVirus stimulationNasal washingsVirus infectionSignificant cell cytotoxicityPotent stimulatorCell cytotoxicityGrowth factorElevated levelsPermeability factorA549 cellsIL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
Corne J, Chupp G, Lee C, Homer R, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman A, Elias J. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. Journal Of Clinical Investigation 2000, 106: 783-791. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/jci9674.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBlotting, WesternBronchoalveolar Lavage FluidEndothelial Growth FactorsEpithelial CellsFibroblast Growth Factor 10Fibroblast Growth Factor 7Fibroblast Growth FactorsGene Expression RegulationGrowth SubstancesHyperoxiaImmunohistochemistryInterleukin-13LungLymphokinesMacrophagesMiceMice, TransgenicMuscle, SmoothOxygenProtein IsoformsSurvival RateVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsAcute lung injuryHyperoxic acute lung injuryIL-13Lung injuryVEGF accumulationProtective effectTransgenic miceRoom airNontransgenic littermate controlsBreathing room airAcid isoformEndothelial cell growth factorVascular endothelial cell growth factorMice breathing room airCell growth factorBronchoalveolar lavageNontransgenic miceLittermate controlsImportant causeAntibody neutralizationMiceGrowth factorInjuryHyperoxiaSurvival
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