Expedient Synthesis of N-Methyl Tubulysin Analogues with High Cytotoxicity
Patterson AW, Peltier HM, Ellman JA. Expedient Synthesis of N-Methyl Tubulysin Analogues with High Cytotoxicity. The Journal Of Organic Chemistry 2008, 73: 4362-4369. PMID: 18479168, DOI: 10.1021/jo800384x.Peer-Reviewed Original ResearchConceptsTubulysin analoguesN-acyl transferExpedient synthesisEfficient synthesisAmide bondN-alkylationTubuvalineStereoselective synthesisOverall yieldO-acylationSynthesisHigher cytotoxicityAnalogue 2Biological studiesHeterocyclesChemistryAnaloguesBondsAminesAcylationLarge quantitiesAlcoholYieldCytotoxicityFormation
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