2019
A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor
Alqadah A, Hsieh YW, Xiong R, Lesch BJ, Chang C, Chuang CF. A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 25137-25146. PMID: 31767767, PMCID: PMC6911211, DOI: 10.1073/pnas.1908168116.Peer-Reviewed Original ResearchConceptsBK potassium channelsNuclear importUnbiased forward genetic screenSpecific nuclear importForward genetic screenCell fate choiceTranscription factor SOX-2Notch-independent mechanismStructure-function insightsPotassium channelsHigh mobility groupProtein kinase pathwayAmino acid residuesAWC asymmetryGenetic screenFunction mutantsHuman neurological disordersAWC neuronsFate choiceKinase pathwayBiological processesAcid residuesMobility groupCalcium signalingSox-2
2009
Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy
Wang L, Sigworth FJ. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature 2009, 461: 292-295. PMID: 19718020, PMCID: PMC2797367, DOI: 10.1038/nature08291.Peer-Reviewed Original ResearchConceptsVoltage sensor domainNative membrane environmentMembrane proteinsMembrane environmentChannel voltage-sensor domainElectron cryomicroscopyVoltage-activated potassium channelsSingle-particle electron cryomicroscopyIndividual protein particlesPotassium channelsBK potassium channelsLarge conductance calciumLipid membranesX-ray crystal structureBK channelsStructural studiesProtein particlesProteinCryomicroscopyCrystal structureFormation of crystalsDomainStructureCrystalsChannelsChapter 19 The Syndrome of Hypertension and Hyperkalemia (Pseudohypoaldosteronism Type II) WNK Kinases Regulate the Balance Between Renal Salt Reabsorption and Potassium Secretion
Kahle K, Wilson F, Lifton R. Chapter 19 The Syndrome of Hypertension and Hyperkalemia (Pseudohypoaldosteronism Type II) WNK Kinases Regulate the Balance Between Renal Salt Reabsorption and Potassium Secretion. 2009, 313-329. DOI: 10.1016/b978-0-12-449851-8.00019-x.ChaptersRenal potassium secretionLumen-negative potentialPotassium secretionPseudohypoaldosteronism type IINa-Cl cotransporterSalt reabsorptionDistal nephron potassium secretionPotassium channelsRenal outer medullary potassium channelENaC activitySyndrome of hypertensionPotential targetElectrogenic sodium reabsorptionPotassium channel ROMKDistal proton secretionRenal salt reabsorptionBK potassium channelsEpithelial sodium channelMolecular genetic discoveriesSodium reabsorptionWNK kinasesProfound hyperkalemiaImpaired productionMarked impairmentChannel ROMK
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply