PapA3 Is an Acyltransferase Required for Polyacyltrehalose Biosynthesis in Mycobacterium tuberculosis *
Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi CR. PapA3 Is an Acyltransferase Required for Polyacyltrehalose Biosynthesis in Mycobacterium tuberculosis *. Journal Of Biological Chemistry 2009, 284: 12745-12751. PMID: 19276083, PMCID: PMC2676004, DOI: 10.1074/jbc.m809088200.Peer-Reviewed Original ResearchConceptsUnusual cell wallBiosynthetic gene clusterSulfolipid-1Cell wall moleculesTrehalose-based glycolipidsGene clusterBiosynthetic machineryPutative acyltransferaseBacterial lipid extractsCell wallMutant strainBiosynthesisWall moleculesPalmitoyl groupsGenesGlycolipidsM. tuberculosisPathogenic M. tuberculosisAcyltransferaseAcyltransferase activityPAT productionTrehaloseLipid extractsComplementationMycobacterium tuberculosis
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