2024
Molecular profiling of metastatic breast cancer and target-based therapeutic matching in an Asian tertiary phase I oncology unit
Walsh R, Ong R, Cheo S, Low P, Jayagopal A, Lee M, Ngoi N, Ow S, Wong A, Lim S, Lim Y, Heong V, Sundar R, Soo R, Chee C, Yong W, Goh B, Lee S, Tan D, Lim J. Molecular profiling of metastatic breast cancer and target-based therapeutic matching in an Asian tertiary phase I oncology unit. Frontiers In Oncology 2024, 14: 1342346. PMID: 38812774, PMCID: PMC11133600, DOI: 10.3389/fonc.2024.1342346.Peer-Reviewed Original ResearchProlonged median progression-free survivalTumor mutational burdenObjective response rateMetastatic breast cancerHazard ratioNext-generation sequencingPhase I unitMedian OSMolecular profilingOverall survivalAssociated with prolonged median PFSBreast cancerMedian progression-free survivalTreatment outcomesTrials of targeted therapiesProgression-free survivalData cut-offBroad-panel next-generation sequencingTumor molecular profilingTreatment eventsFoundationOne CDxMBC patientsMutational burdenAssociated with improvementsTertiary centre
2022
First report from the American Society of Metabolic and Bariatric Surgery closed-claims registry: prevalence, causes, and lessons learned from bariatric surgery medical malpractice claims
Morton JM, Khoury H, Brethauer SA, Baker JW, Sweet WA, Mattar S, Ponce J, Nguyen NT, Rosenthal RJ, DeMaria EJ. First report from the American Society of Metabolic and Bariatric Surgery closed-claims registry: prevalence, causes, and lessons learned from bariatric surgery medical malpractice claims. Surgery For Obesity And Related Diseases 2022, 18: 943-947. PMID: 35595651, DOI: 10.1016/j.soard.2022.04.004.Peer-Reviewed Original ResearchConceptsBariatric surgeryMalpractice claimsClosed claimsClosed claim filesPostoperative careClinical complicationsVascular injuryUniversity HospitalCommon causeClinical summaryForeign bodyHospital statusSustained improvementMedical malpractice claimsSurgeryTreatment eventsExpert panelPrevalencePrivate practiceComplicationsMalpractice insurerAmerican SocietyRegistryHospitalHigh rate
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