2016
Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma
Rubinstein JC, Brown TC, Christison-Lagay ER, Zhang Y, Kunstman JW, Juhlin CC, Nelson-Williams C, Goh G, Quinn CE, Callender GG, Udelsman R, Lifton RP, Korah R, Carling T. Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma. BMC Cancer 2016, 16: 646. PMID: 27538953, PMCID: PMC4989347, DOI: 10.1186/s12885-016-2665-7.Peer-Reviewed Original ResearchConceptsSingle nucleotide substitutionSomatic evolutionCommon ancestor cellGenomic changesNucleotide substitutionsTissue typesTissue-specific signaturesGenomic divergenceGenomic variationGenomic instabilityGenomic signaturesRisk of tumorigenesisSelective pressurePTC tumorigenesisTumor genomesAncestor cellsGenomeA transversionMethodsExome sequencingDiverse mutationsSomatic eventsMutational spectrumT transitionNovel patternTumorigenesis
2007
The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature.
Fortier M, Caron E, Hardy M, Voisin G, Lemieux S, Perreault C, Thibault P. The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature. Blood 2007, 110: 1327. DOI: 10.1182/blood.v110.11.1327.1327.Peer-Reviewed Original ResearchSource mRNATissue-specific signaturesBiological replicatesPrimary mouse thymocytesEL4 cellsNeoplastic transformationRelative quantificationCancer cellsRelative expressionExpression ratioMass spectrometry approachMRNA levelsAbundant transcriptsTranscriptomic dataHigh-throughput analysisMHC IPosttranscriptional mechanismsNeoplastic thymocytesSurvival signalsNormal thymocytesSource proteinsRelative abundanceIntracellular pathogensSpearman correlation coefficientNeoplastic cells
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