2024
Stable-Isotope N‑Me Aziridination Enables Accurate Quantitative CC Isomeric Lipidomics
Feng G, Gao M, Chen H, Zhang Z, Chen J, Tong Y, Wu P, Fu R, Lin Y, Chen S. Stable-Isotope N‑Me Aziridination Enables Accurate Quantitative CC Isomeric Lipidomics. Analytical Chemistry 2024, 96: 2524-2533. PMID: 38308578, DOI: 10.1021/acs.analchem.3c04824.Peer-Reviewed Original ResearchConceptsC-C bondsAccurate lipid quantificationAccurate relative quantificationOne-step introductionLipid isomersC bondSimultaneous qualificationLarge-scale resolutionMouse brain ischemiaStructural resolutionRelative quantificationUnsaturated lipidsLipid quantificationAccurate quantificationBrain ischemiaIsomersQuantificationActive groupEsterReactionPositive identificationPathological processesCholesterol estersLipidomics
2007
The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature.
Fortier M, Caron E, Hardy M, Voisin G, Lemieux S, Perreault C, Thibault P. The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature. Blood 2007, 110: 1327. DOI: 10.1182/blood.v110.11.1327.1327.Peer-Reviewed Original ResearchSource mRNATissue-specific signaturesBiological replicatesPrimary mouse thymocytesEL4 cellsNeoplastic transformationRelative quantificationCancer cellsRelative expressionExpression ratioMass spectrometry approachMRNA levelsAbundant transcriptsTranscriptomic dataHigh-throughput analysisMHC IPosttranscriptional mechanismsNeoplastic thymocytesSurvival signalsNormal thymocytesSource proteinsRelative abundanceIntracellular pathogensSpearman correlation coefficientNeoplastic cells
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