2018
Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology
Rapanelli M, Frick L, Jindachomthong K, Xu J, Ohtsu H, Nairn A, Pittenger C. Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology. Neuroscience 2018, 392: 172-179. PMID: 30278251, PMCID: PMC6204318, DOI: 10.1016/j.neuroscience.2018.09.035.Peer-Reviewed Original ResearchConceptsHDC-KO miceMitogen-activated protein kinaseHistamine receptorsWT animalsDorsal striatumH3R activationTic-like movementsStriatonigral medium spiny neuronsAkt phosphorylationMedium spiny neuronsWild-type miceRare genetic causeHistamine dysregulationAgonist treatmentKO miceSpiny neuronsTic disordersTic pathophysiologyStriatal signalingMouse modelNeuropsychiatric diseasesKO modelRepetitive movementsStriatumMice
2016
Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming
Xu M, Li L, Pittenger C. Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming. Neuroscience 2016, 324: 321-329. PMID: 26968763, PMCID: PMC4838496, DOI: 10.1016/j.neuroscience.2016.02.074.Peer-Reviewed Original ResearchConceptsTourette syndromeTic disordersRepetitive movementsCortico-basal ganglia loopsTic-like movementsRefractory Tourette syndromeNormal adult miceAnxiety-like behaviorPost-mortem studiesStereotypic groomingStriatal interneuronsPrepulse inhibitionSensorimotor gatingDorsal striatumAdult miceAblation approachSpontaneous stereotypyAcute stressInterneuronsCausal roleSyndromePathologyDeficitsDisordersStereotypy
2008
Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements
Hampson M, Tokoglu F, King RA, Constable RT, Leckman JF. Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements. Biological Psychiatry 2008, 65: 594-599. PMID: 19111281, PMCID: PMC2679868, DOI: 10.1016/j.biopsych.2008.11.012.Peer-Reviewed Original ResearchConceptsMotor cortexSupplementary motor areaControl subjectsBrain areasMotor ticsTic disordersTic movementsMotor areaTic-like movementsHealthy control subjectsChronic tic disorderNormal control subjectsChronic motor ticsNovel intervention strategiesFunctional neuroimaging studiesTic executionSevere ticsIntentional movementPatient's ticsMotor regionsPremonitory urgesBrain activity patternsAdult subjectsTic generationCortex
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