2002
Models of Eukaryotic Gradient Sensing: Application to Chemotaxis of Amoebae and Neutrophils
Levchenko A, Iglesias P. Models of Eukaryotic Gradient Sensing: Application to Chemotaxis of Amoebae and Neutrophils. Biophysical Journal 2002, 82: 50-63. PMID: 11751295, PMCID: PMC1302448, DOI: 10.1016/s0006-3495(02)75373-3.Peer-Reviewed Original ResearchConceptsPersistent signalingBiochemical signal transduction pathwaysSmall G proteinsChemotaxis of amoebaeSignal transduction pathwaysG protein activationEukaryotic cellsGradient sensingEukaryotic gradient sensingG proteinsCell typesSignal gradientExquisite precisionChemoattractant gradientPerfect adaptationSignalingAmoebaeActivatorPositive feedbackSensory systemsContinuous presenceAdaptationShallow gradientsChemoattractantInactivator
1997
DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.
Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Research 1997, 57: 1013-9. PMID: 9067261.Peer-Reviewed Original ResearchConceptsDNA rereplicationBiochemical signal transduction pathwaysSignal transduction pathwaysCell cycle checkpointsPRb tumor suppressorSpindle assemblyCycle checkpointsTransduction pathwaysRereplicationDownstream eventsMitotic divisionTumor suppressorMouse fibroblastsCell ploidyDNA contentDeficient derivativeHuman fibroblastsSpindle inhibitorsP53Cytogenetic analysisMitotic spindle inhibitorsFibroblastsPolyploidyMitosisSuppressor
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