2022
Disease‐modifying therapies and T1 hypointense lesions in patients with multiple sclerosis: A systematic review and meta‐analysis
Valizadeh A, Fattahi M, Sadeghi M, Torbati M, Sahraian M, Azimi A. Disease‐modifying therapies and T1 hypointense lesions in patients with multiple sclerosis: A systematic review and meta‐analysis. CNS Neuroscience & Therapeutics 2022, 28: 648-657. PMID: 35218155, PMCID: PMC8981477, DOI: 10.1111/cns.13815.Peer-Reviewed Original ResearchConceptsDisease-modifying therapiesCertainty of evidenceVolumes of T1Hypointense lesionsMultiple sclerosis patientsRisk of biasRoB 2 toolT1-hypointense lesionsRandom-effects modelEffects of FDANumber of lesionsAdult patientsSclerosis patientsMultiple sclerosisComparator groupPrognostic markerObjective markersSystematic reviewLesionsMean differenceMean volumePatientsRelevant studiesHypointenseTherapy
2021
Correlation between the clinical disability and T1 hypointense lesions’ volume in cerebral magnetic resonance imaging of multiple sclerosis patients: A systematic review and meta‐analysis
Valizadeh A, Moassefi M, Barati E, Sahraian M, Aghajani F, Fattahi M. Correlation between the clinical disability and T1 hypointense lesions’ volume in cerebral magnetic resonance imaging of multiple sclerosis patients: A systematic review and meta‐analysis. CNS Neuroscience & Therapeutics 2021, 27: 1268-1280. PMID: 34605190, PMCID: PMC8504532, DOI: 10.1111/cns.13734.Peer-Reviewed Original ResearchConceptsMean volumeCerebral magnetic resonance imagingPrognosis Studies toolMultiple sclerosis patientsRisk of biasT1-hypointense lesionsRandom-effects modelMagnetic resonance imagingWeb of ScienceClinical disabilityAdult patientsCerebral MRIEDSS scoreSclerosis patientsMultiple sclerosisDisability levelHypointense lesionsSystematic reviewResonance imagingPatientsRelevant studiesStudy toolCorrelation coefficientT1EDSS
2015
Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study
Miller D, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wheeler-Kingshott C, Tozer D, MacManus D, Yousry T, Goodsell M, Yang M, Zhang R, Viglietta V, Dawson K, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wilson K, Yang M, Dawson K, Antel J, Ware J, Polman C, Kowey P, Chung R, Bakris G, Richert J, Seibert B, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Alfaro-Vidal T, Crespo C, Foster J, Hunter K, Garcia-Gomez A, MacManus D, Miller D, Santana V, Tozer D, Wheeler-Kingshott C, Yousry T, Kneebone C, Fedulau A, Likhachev S, Mikhailova E, Naumova H, Decoo D, Gaer L, Sindic C, Grgic S, Sinanovic O, Suljic E, Deleva N, Georgiev D, Haralanov L, Ivanova S, Manchev I, Minchev D, Stamenova P, Tournev I, Vacheva E, Zahariev Z, Bar-Or A, Blevins G, Kremenchutzky M, Veloso F, Witt N, Vargas Howell R, Vindas A, Habek M, Rudež J, Soldo-Butković S, Vurdelja R, Doležil D, Havrdova E, Nova'k J, Vaclavik D, Antsov K, Gross-Paju K, Haldre S, Palu A, Toomsoo T, Al Khedr A, Camu W, Debouverie M, Defer G, De Seze J, Labauge P, Moreau T, Pelletier J, Rumbach L, Daskalovska V, Angnstwurm K, Benes H, Berthele A, Boldt H, Christopher A, Derfuß T, Eisensehr I, Emrich P, Feneberg W, Hoffmann F, Hohlfeld R, Hüntemann R, Kallmann B, Kieseier B, Landefeld H, Lüer W, Masri S, Nelles G, Oschmann P, Paschen C, Reifschneider G, Sailer M, Schimrigk S, Spiegel-Meixensberger M, Storch-Hagenlocher B, Tackenberg B, Tiel-Wilck K, Karageorgiou C, Papathanasopoulos P, Thomaides T, Vlaikidis N, Arjundas D, Behari M, Ghosh A, Ghosh P, Ichaporia N, Khurana D, Kulkarni R, Kumar S, Mehndiratta M, Mehta N, Misra U, Mukherji J, Nellikunja S, Salem A, Sethi P, Shah S, Singh G, Singh M, Singh Y, Srinivasa R, Vijayan K, Hutchinson M, Sweeney B, Gilad R, Shahien R, Paegle A, Delgado C, Escamilla J, Estañol B, Lopez M, Macias M, Punzo G, Quiñones S, Renteria M, Santos J, Gavriliuc M, Groppa S, Odainic O, Timmings P, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kaminska A, Kapelusiak-Pielok M, Kleczkowska M, Kochanowicz J, Losy J, Nowacki P, Nyka W, Pierzchala K, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Szczudlik A, Tutaj A, Wajgt A, Zielinski T, Balasa R, Ionescu-Dimancea V, Mihancea P, Popescu C, Protosevici L, Miletić Drakulić S, Nadj C, Raicevic R, Vojinovic S, Kahancová E, Kurca E, Lisý L, Turčáni P, Arroyo R, Fernández O, Guijarro C, Izquierdo G, Lopez F, Montalbán X, Oreja-Guevara C, Prieto J, Buchakchyys'ka N, Chmyr G, Goloborodko A, Kobys T, Kushnir G, Lebedynets V, Lytvynenko N, Moskovko S, Nehrych T, Palamar B, Pasyura I, Ryabichenko T, Voloshina N, Apperson M, Applebee A, Asher S, Ayala R, Ayres D, Azizi S, Baker M, Bauer B, Bomprezzi R, Buckler R, Carlini W, Chinea A, Cohan S, Crowell G, Edwards K, Eubank G, Felton W, Fodor P, Foley J, Ford C, Fox E, Fox R, Forester M, Freedman S, Garmany G, Gazda S, Giang D, Glaun B, Gold S, Gottesman M, Gudesblatt M, Herbert J, Herskowitz A, Honeycutt W, Huddlestone J, Hull R, Hunter S, Hutton G, Jacobs D, Janicki M, Khatri B, Kinkel R, Kita M, Krolczyk S, Krupp L, LaGanke C, Levin M, Licht J, Luzzio C, Lynch S, Mattson D, Mikol D, Miller T, Minagar A, Mitchell G, Moses H, Negroski D, Newman S, Pardo G, Patel M, Perel A, Phillips J, Picone M, Rammohan K, Rao T, Rinker J, Sadiq S, Schaeffer J, Sheremata W, Shin R, Shubin R, Silverman S, Smith R, Stein L, Stein M, Steiner D, Steingo B, Sullivan H, Sunter W, Vaishnav A, Vasquez A, Voci J, Warach J, Weinstock-Guttman B, Williams M, Wray S. Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study. Neurology 2015, 84: 1145-1152. PMID: 25681448, PMCID: PMC4371413, DOI: 10.1212/wnl.0000000000001360.Peer-Reviewed Original ResearchConceptsRelapsing-remitting multiple sclerosisDelayed-release dimethyl fumarateMagnetization transfer ratioLesion activityEffects of delayed-release dimethyl fumarateMultiple sclerosisVolume of T2-hyperintensityActive lesion countsSubcutaneous glatiramer acetatePlacebo-controlled studyMRI lesion activityT2 hyperintense lesionsDimethyl fumarateMagnetization transfer ratio changesT1-hypointense lesionsYear of treatmentClass I evidenceInflammatory lesion activitySafety of DMFDMF BIDDMF therapyOral fumarateGd+ lesionsGadolinium enhancementGlatiramer acetate
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply