2025
IMPROVED OUTCOMES IN BCG-UNRESPONSIVE BLADDER CANCER PATIENTS WITH NON-INVASIVE DISEASE UNDERGOING BLADDER SPARING THERAPY COMPARED TO T1 DISEASE: RESULTS FROM AN INTERNATIONAL COHORT
Annapureddy D, Taylor J, Howard J, Tan W, McElree I, Davaro F, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, O'Donnell M, Kamat A, Woldu S, Lotan Y. IMPROVED OUTCOMES IN BCG-UNRESPONSIVE BLADDER CANCER PATIENTS WITH NON-INVASIVE DISEASE UNDERGOING BLADDER SPARING THERAPY COMPARED TO T1 DISEASE: RESULTS FROM AN INTERNATIONAL COHORT. Urologic Oncology Seminars And Original Investigations 2025, 43: 80-81. DOI: 10.1016/j.urolonc.2024.12.203.Peer-Reviewed Original ResearchBCG-unresponsive NMIBCNon-muscle invasive bladder cancerBladder sparing therapyAll-Cause MortalityOncological outcomesRadical cystectomyCancer-specific mortalityNon-invasive diseaseBCG-unresponsiveBladder cancerPathological outcomesT1 diseaseT1 patientsCIS patientsMedian timeProgression to muscle-invasive bladder cancerBCG-unresponsive NMIBC patientsImpact of pathological stageImpact of tumor stageInternational cohortMuscle-invasive bladder cancerAssociated with significant morbiditySingle-institution seriesHeterogeneous group of patientsCompare oncologic outcomesImpact of Tumor Stage on Oncologic Outcomes of High-grade Bacillus Calmette-Guérin Unresponsive Non–muscle-invasive Bladder Cancer Undergoing Bladder-sparing Therapies
Annapureddy D, Taylor J, Kamat A, O'Donnell M, Howard J, Tan W, McElree I, Davaro F, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, Woldu S, Lotan Y. Impact of Tumor Stage on Oncologic Outcomes of High-grade Bacillus Calmette-Guérin Unresponsive Non–muscle-invasive Bladder Cancer Undergoing Bladder-sparing Therapies. European Urology Focus 2025 PMID: 39922753, DOI: 10.1016/j.euf.2025.01.001.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerCarcinoma in situBCG-unresponsive NMIBCBladder-sparing therapyOncological outcomesTumor stageBladder cancer mortalityCancer mortalityAssociated with worse oncologic outcomesPresence of carcinoma in situCarcinoma in situ groupImpact of tumor stageTA groupKaplan-Meier methodPapillary diseaseT1 diseaseRadical cystectomyNo significant differenceClinical stageBladder cancerSurvival differencesRetrospective natureCis groupDisease progressionMetastasis
2017
Hypofractionated Radiotherapy for Patients with Early-Stage Glottic Cancer: Patterns of Care and Survival
Bledsoe TJ, Park HS, Stahl JM, Yarbrough WG, Burtness BA, Decker RH, Husain ZA. Hypofractionated Radiotherapy for Patients with Early-Stage Glottic Cancer: Patterns of Care and Survival. Journal Of The National Cancer Institute 2017, 109: djx042. PMID: 28521361, DOI: 10.1093/jnci/djx042.Peer-Reviewed Original ResearchConceptsEarly-stage glottic cancerOverall survivalGlottic cancerMultivariable Cox proportional hazards regressionNational Comprehensive Cancer Network guidelinesNational Cancer Data BaseCox proportional hazards regressionPropensity scoreClinical T1 diseaseImproved overall survivalHigh-volume centersProportional hazards regressionLog-rank testPatterns of careRadiation treatment schedulesLarge national databaseCT2 diseaseDefinitive radiotherapyT1 diseaseHypofractionated radiotherapyImproved survivalMultivariable analysisTreatment patternsHazards regressionNetwork guidelines
2014
Is local resection adequate for T1 stage ampullary cancer?
Amini A, Miura J, Jayakrishnan T, Johnston F, Tsai S, Christians K, Gamblin T, Turaga K. Is local resection adequate for T1 stage ampullary cancer? Hepato Pancreato Biliary 2014, 17: 66-71. PMID: 25395092, PMCID: PMC4266442, DOI: 10.1111/hpb.12297.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overAmpulla of VaterCommon Bile Duct NeoplasmsEndoscopy, Digestive SystemFemaleHumansKaplan-Meier EstimateLymph Node ExcisionLymphatic MetastasisMaleMiddle AgedNeoplasm StagingPancreaticoduodenectomyPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk FactorsSEER ProgramSurvival RateTime FactorsTreatment OutcomeUnited StatesWatchful WaitingConceptsAmpullary cancerRegional lymphadenectomyT1 diseaseLocal resectionFive-year survival rateAssociated with node positivityHigher-grade lesionsData of patientsLong-term survivalCases of ACNodal diseaseMetastatic diseaseNodal clearanceNodal metastasisHistological typeEndoscopic resectionEndoscopic surveillancePancreaticoduodenectomyLymphadenectomyAmpullectomySurvival rateHigh riskPatientsMultivariate modelResection
2000
Smoking and alcohol use may be risk factors for poorer outcome in patients with clear cell renal carcinoma
Oh W, Manola J, Renshaw A, Brodkin D, Loughlin K, Richie J, Shapiro C, Kantoff P. Smoking and alcohol use may be risk factors for poorer outcome in patients with clear cell renal carcinoma. Urology 2000, 55: 31-35. PMID: 10654890, DOI: 10.1016/s0090-4295(99)00408-2.Peer-Reviewed Original ResearchConceptsClear cell renal carcinomaRecurrence-free survival ratesCell renal carcinomaStage M0Renal carcinomaSurvival rateFuhrman gradeRetrospective review of clinical recordsAlcohol useRisk factorsAssociated with overall survivalReview of clinical recordsRecurrence-free survivalMedian Follow-UpAssociated with increased mortalityOverall survival ratePrognosis of clear cell renal carcinomaRegular alcohol useAlcohol use historyT1 diseaseSuspected metastasesOverall survivalLocalized diseaseNephrectomy specimensT classification
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