Durable Macrochimerism (>8 weeks) and Pig-Specific T and B Cell Unresponsiveness Following hCD47+ Transgenic GalTKO Pig Intra-Bone Bone Marrow Transplantation in Baboons
Watanabe H, Nomura S, Ariyoshi Y, Pomposelli T, Boyd L, Tasaki M, Ekanayake-Alper D, Glor H, Arn S, Hawley R, Sykes M, Sachs D, Yamada K. Durable Macrochimerism (>8 weeks) and Pig-Specific T and B Cell Unresponsiveness Following hCD47+ Transgenic GalTKO Pig Intra-Bone Bone Marrow Transplantation in Baboons. Transplantation 2018, 102: s391. DOI: 10.1097/01.tp.0000543158.20137.b0.Peer-Reviewed Original ResearchPorcine BM cellsBM cellsBone marrowNAb levelsT cell responses in vitroAntibody responsePorcine BMPig-to-non-human primate modelsPig-to-baboon modelMaintained blood levelsT cell responsesAnti-CD40L antibodyBone marrow transplantationB cell unresponsivenessB cell toleranceWhole-body irradiationResponses in vitroTransgenic pigsPig-to-baboonPig bone marrowConditioning regimenXenogeneic chimerismBody irradiationMarrow transplantationPersistent chimerism
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