An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration
Leventhal M, Zanella C, Kang B, Peng J, Gritsch D, Liao Z, Bukhari H, Wang T, Pao P, Danquah S, Benetatos J, Nehme R, Farhi S, Tsai L, Dong X, Scherzer C, Feany M, Fraenkel E. An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration. Nature Communications 2025, 16: 4441. PMID: 40393985, PMCID: PMC12092734, DOI: 10.1038/s41467-025-59654-w.Peer-Reviewed Original ResearchConceptsDisease proteomicsDrosophila model of Alzheimer's diseaseAlzheimer's diseaseDisease neurodegenerationSystems-biology approachAlzheimer's disease neurodegenerationModel of Alzheimer's diseaseModify gene expressionAge-associated neurodegenerationDrosophila modelTau proteinGenetic screeningGenetic variantsGene expressionRelevant pathwaysDNA damageAmeliorate neurodegenerationDrosophilaYears of intensive investigationNeural progenitor cellsProteomicsNeurodegenerationNeuronal deathAlzheimerProgenitor cells
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