2024
Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei
Beaver A, Keneskhanova Z, Cosentino R, Weiss B, Awuoche E, Smallenberger G, Buenconsejo G, Crilly N, Smith J, Hakim J, Zhang B, Bobb B, Rijo-Ferreira F, Figueiredo L, Aksoy S, Siegel T, Mugnier M. Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei. Nature 2024, 636: 430-437. PMID: 39478231, PMCID: PMC11634766, DOI: 10.1038/s41586-024-08151-z.Peer-Reviewed Original ResearchVariant surface glycoproteinAntigenic diversityAntigenic variationHigh-throughput sequencing approachDense variant surface glycoproteinPopulations of T. bruceiDynamics of antigenic variationGenomic repertoirePathogen diversificationSequencing approachExtravascular spaceTrypanosoma bruceiVariation in vivoHost immune systemAntigenic variation in vivoSurface glycoproteinSlow immune responseDiversitySwitching expressionParasite populations
2010
HER2 Silences Tumor Suppression in Breast Cancer Cells by Switching Expression of C/EBPβ Isoforms
Arnal-Estapé A, Tarragona M, Morales M, Guiu M, Nadal C, Massagué J, Gomis R. HER2 Silences Tumor Suppression in Breast Cancer Cells by Switching Expression of C/EBPβ Isoforms. Cancer Research 2010, 70: 9927-9936. PMID: 21098707, DOI: 10.1158/0008-5472.can-10-0869.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBlotting, WesternBreast NeoplasmsCCAAT-Enhancer-Binding Protein-betaCell LineCell Line, TumorCellular SenescenceGene Expression Regulation, NeoplasticHumansIn Situ Hybridization, FluorescenceMiceMice, NudePhosphorylationPromoter Regions, GeneticProtein BindingProtein BiosynthesisProtein IsoformsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycReceptor, ErbB-2Reverse Transcriptase Polymerase Chain ReactionRNA InterferenceTransforming Growth Factor betaTrastuzumabConceptsBreast cancer cellsTumor suppressionBreast cancerOncogene-induced senescenceCancer cellsHER2-overexpressing breast cancer cellsSubtypes of breast cancerHER2 antibody trastuzumabTransforming growth factor-bBreast cancer developmentGrowth factor BTranscriptional repressor complexHER2 signalingSuppressor responseTumor progressionMammary epithelial cellsAntibody trastuzumabHER2Cancer developmentEpithelial cellsSuppressor functionSwitching expressionInterfere with activitiesMYC promoterBreast
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply