2015
Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice
Hatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan MJ, Ueno Y, Tsukita S, Asano S. Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice. Hepatology 2015, 61: 1660-1671. PMID: 25311759, PMCID: PMC6083834, DOI: 10.1002/hep.27565.Peer-Reviewed Original ResearchConceptsBile duct proliferationIntrahepatic cholestasisDuct proliferationExtensive bile duct proliferationBiliary HCO3- concentrationImmortalized mouse cholangiocytesSevere intrahepatic cholestasisAquaporin-1Cystic fibrosis transmembrane conductance regulatorBile duct epitheliumBile acid accumulationSurface expressionBile duct morphologyReduced functional expressionPeriportal fibrosisBile ductInflammatory cellsBile flowCholestatic diseasePeriductular fibrosisBiliary epitheliumHepatic disordersAnion exchanger 2Useful modelVirus infection
1998
Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver
Koeppel T, Trauner M, Albert M, Arrese M, Rios-Velez L, Boyer J. Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver. Journal Of Hepatology 1998, 28: 812-819. PMID: 9625316, DOI: 10.1016/s0168-8278(98)80231-6.Peer-Reviewed Original ResearchConceptsBiliary glutathione excretionBile duct injuryCold ischemiaBile flowHepatic bile formationDuct injuryLiver transplantationBiliary tractBiliary excretionRat liverGlutathione excretionBasal bile flow ratesBile formationBile acid-independent bile flowOxidative stressLate reperfusion periodBile duct damageBile flow rateOnset of reperfusionIndependent bile flowBile duct morphologyBiliary glutathione concentrationsWistar rat liverLiver reperfusionDuct damage
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