2015
Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei
Ramey-Butler K, Ullu E, Kolev NG, Tschudi C. Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei. Molecular And Biochemical Parasitology 2015, 200: 1-4. PMID: 25896436, PMCID: PMC4470760, DOI: 10.1016/j.molbiopara.2015.04.001.Peer-Reviewed Original ResearchConceptsVariant surface glycoproteinMetacyclic variant surface glycoproteinInfectious metacyclic formsVariant surface glycoprotein genesVSG gene expressionSurface glycoprotein genesNew mammalian hostInsect vectorsParasite biologyMammalian hostsDifferentiation systemGene expressionTsetse vectorBloodstream trypanosomesDifferential expressionGlycoprotein geneProtein 6Molecular aspectsIndividual cellsMetacyclic formsBlood mealProtein levelsDiscrete populationsSurface glycoproteinLife cycle
2007
Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi
Ekanayake D, Cipriano M, Sabatini R. Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Nucleic Acids Research 2007, 35: 6367-6377. PMID: 17881368, PMCID: PMC2095807, DOI: 10.1093/nar/gkm693.Peer-Reviewed Original ResearchConceptsTelomeric repeat sequencesBase JVariant surface glycoproteinRepeat sequencesGenes adjacent to telomeresExpression sitesAnalysis of DNA sequencesBeta-d-glucosylhydroxymethyluracilAdjacent to telomeresGene expression sitesSouth American trypanosomesSurface glycoprotein genesActive expression siteContingency genesSubtelomeric regionsTelomeric repeatsDNA sequencesAmerican trypanosomesDNA digestionTelomeric genesTrypanosoma bruceiSouthern blottingTelomere distributionKinetoplastid parasitesGlycoprotein geneJBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei
Kieft R, Brand V, Ekanayake D, Sweeney K, DiPaolo C, Reznikoff W, Sabatini R. JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Molecular And Biochemical Parasitology 2007, 156: 24-31. PMID: 17706299, PMCID: PMC4735730, DOI: 10.1016/j.molbiopara.2007.06.010.Peer-Reviewed Original ResearchConceptsSWI2/SNF2-like proteinsBase JRegulation of antigenic variationTelomeric variant surface glycoprotein genesAntigenic variationBloodstream form Trypanosoma bruceiVariant surface glycoprotein genesBloodstream form trypanosomesSurface glycoprotein genesTelomere arraysChromatin remodelingEpigenetic silencingJBP2Telomeric DNARegulatory mechanismsGlycoprotein geneTrypanosome DNASite-specific localizationProteinThymine baseChromatinBiosynthesisGenesDNAGlycosylation
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