Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis
Schumacher MA, Chinnam NB, Cuthbert B, Tonthat NK, Whitfill T. Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. Genes & Development 2015, 29: 451-464. PMID: 25691471, PMCID: PMC4335299, DOI: 10.1101/gad.254714.114.Peer-Reviewed Original ResearchConceptsGlutamine synthetaseFeedback-inhibited glutamine synthetaseMolecular mechanismsDimeric DNA-binding proteinsNitrogen homeostasisDNA-binding proteinsSuch regulatory pathwaysDetailed molecular mechanismsNovel molecular mechanismGram-positive bacterium B. subtilisRegulatory machineryTranscription regulatorsMolecular dissectionBacterium B. subtilisNutrient availabilityRegulatory pathwaysNitrogen depletionMetabolic reprogramingTnrAC-terminalB. subtilisBacillus subtilisNew structural familyNitrogen excessStructural family
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