2003
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine
Peakman M, Colby C, Perrotti L, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen M, Stock J, Duman R, McNeish J, Barrot M, Self D, Nestler E, Schaeffer E. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Research 2003, 970: 73-86. PMID: 12706249, DOI: 10.1016/s0006-8993(03)02230-3.Peer-Reviewed Original ResearchConceptsNucleus accumbensFos proteinAdult miceRewarding effectsTransgenic miceBrain regionsBrain region-specific expressionCocaine-induced locomotor activityTranscription factor nuclear factor-kappaBRegion-specific expressionAdministration of cocaineChronic drug administrationGlutamate receptor subunit GluR2Chronic cocaine administrationNuclear factor-kappaBProtein kinase Cdk5C-JunAP-1-mediated transcriptionCocaine administrationFos responsePlace preferenceSubunit GluR2Drug AdministrationFactor-kappaBLocomotor activity
1999
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz M, Chen J, Carlezon W, Whisler K, Gilden L, Beckmann A, Steffen C, Zhang Y, Marotti L, Self D, Tkatch T, Baranauskas G, Surmeier D, Neve R, Duman R, Picciotto M, Nestler E. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 1999, 401: 272-276. PMID: 10499584, DOI: 10.1038/45790.Peer-Reviewed Original ResearchConceptsNucleus accumbensGlutamate receptor subunit GluR2Locomotor-activating effectsFos family transcription factorsTranscription factor ΔFosBDrugs of abuseΔFosB expressionAcute exposureTransgenic miceChronic exposureSubunit GluR2ΔFosBCocaine addictionAccumbensCocainePersistent expressionTranscription factorsSustained accumulationBrainExposureStable isoformSubset of nucleiExpressionGene expressionMorphine
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