2024
Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors
Dixon R, Malave L, Thompson R, Wu S, Li Y, Sadik N, Anacker C. Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors. Neuropsychopharmacology 2024, 50: 507-518. PMID: 39396089, PMCID: PMC11736140, DOI: 10.1038/s41386-024-01999-9.Peer-Reviewed Original ResearchEffects of early life adversityEarly life adversityVentral dentate gyrusAcute swim stressCorticotropin-releasing factorStress reactivityParaventricular nucleusSwim stressLife adversityNeuronal activityModel of early life adversityEarly life adversity effectsIn adulthoodIncreased passive copingSex-specific impairmentsFemale miceSerotonin-1ASerotonin systemNeurobiological mechanismsStress vulnerabilityIncreased microglia activationLimited beddingPassive copingAutoreceptorsCorticosterone levels
2008
Past Depression and Gender Interact to Influence Emotional Reactivity to Daily Life Stress
Husky M, Mazure C, Maciejewski P, Swendsen J. Past Depression and Gender Interact to Influence Emotional Reactivity to Daily Life Stress. Cognitive Therapy And Research 2008, 33: 264-271. DOI: 10.1007/s10608-008-9212-z.Peer-Reviewed Original ResearchHealthy controlsPrior episodesPast depressionDaily stressorsFemale genderPrior depressionPsychiatric illnessEmotional reactivityDepressed menDaily life stressPrevalence changesRemitted depressionDepressed moodDepressionWomenLife stressStress vulnerabilityMenEpisodesGender differencesGreater emotional reactivityIllness
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