2025
Perspective Chapter: From Embryonic Archives to Translational Insights – Reusing Nonhuman Primate Brain Data to Decode Development and Reduce Animal Sacrifice
Duque A, Barello P, Greene L, Burke E, Mendoza-Silva V, M. Morozov Y, Rakic P. Perspective Chapter: From Embryonic Archives to Translational Insights – Reusing Nonhuman Primate Brain Data to Decode Development and Reduce Animal Sacrifice. 2025 DOI: 10.5772/intechopen.1011631.Peer-Reviewed Original ResearchNonhuman primatesBrain areasSubcortical regionsDecoding developmentBrain studiesBrain developmentBrain sizeAnimal sacrificeSexual dimorphismTranslational insightsBrainNormal controlsStructural maturationAverage bodyRhesus macaquesStudy of neurogenesisBrain dataArchivalReduce animal sacrificeInterindividual variabilityNeurogenesisEmbryonic ageThe conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation
Stacey J, Hrebík D, Nand E, Shetty S, Qu K, Boicu M, Anders-Össwein M, Uchil P, Dick R, Mothes W, Kräusslich H, Müller B, Briggs J. The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation. Nature 2025, 640: 258-264. PMID: 40011770, PMCID: PMC11964938, DOI: 10.1038/s41586-025-08624-9.Peer-Reviewed Original ResearchSpacer peptide 2Membrane-binding domainVirus particlesProtein-protein interfacesCleavage site mutantsHigh-resolution structuresFusion of virusImmature virus particlesHIV-1Site mutantsProteolytic cleavageFunctional domainsHuman immunodeficiency virus type 1Bound lipidsImmunodeficiency virus type 1Infectious virionsHIV-1 componentsStructural polyprotein GagMature latticeProtein latticeVirus type 1Structural maturationMonolayers in vitroPeptide 2Polyprotein Gag
2014
Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation
Choi BJ, Imlach WL, Jiao W, Wolfram V, Wu Y, Grbic M, Cela C, Baines RA, Nitabach MN, McCabe BD. Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation. Neuron 2014, 82: 618-634. PMID: 24811381, PMCID: PMC4022839, DOI: 10.1016/j.neuron.2014.03.012.Peer-Reviewed Original ResearchConceptsSynaptic terminal growthMiniature neurotransmissionStructural maturationSingle synaptic vesiclesExchange factorDevelopmental roleRac1 GTPaseEssential functionsMiniature eventsSynaptic vesiclesSynapse maturationMiniature postsynaptic potentialsTerminal growthMaturationTranssynaptic processSmall amplitude eventsPostsynaptic potentialsGlutamatergic synapsesPresynaptic neuronsChemical synapseNeurotransmissionGTPaseVesiclesGuanineSynapses
1991
Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.
Lidow M, Goldman-Rakic P, Rakic P. Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 10218-10221. PMID: 1658799, PMCID: PMC52899, DOI: 10.1073/pnas.88.22.10218.Peer-Reviewed Original Research
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