2019
BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma
Sachdeva R, Wu M, Johnson K, Kim H, Celebre A, Shahzad U, Graham M, Kessler J, Chuang J, Karamchandani J, Bredel M, Verhaak R, Das S. BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma. Scientific Reports 2019, 9: 14569. PMID: 31602000, PMCID: PMC6787003, DOI: 10.1038/s41598-019-51270-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBone Morphogenetic Protein 4Bone Morphogenetic ProteinsBrain NeoplasmsCell DivisionCell Line, TumorCell ProliferationDisease ProgressionDrug Resistance, NeoplasmGlioblastomaGliomaHomeostasisHumansMiceMice, Inbred NODNeoplasm Recurrence, LocalNeoplasm TransplantationNeoplastic Stem CellsPhenotypeRNA, Small InterferingSequence Analysis, RNASignal TransductionTemozolomideTransforming Growth Factor betaTransforming Growth Factor beta1ConceptsBMP pathway activationStem cell homeostasisStem cell systemStem cell quiescenceStem cell populationCancer stem cell populationInhibits cell proliferationStem-like cellsCancer stem cellsCell quiescenceCell homeostasisFunctional identityDismal prognosisTemozolomide chemotherapyCytotoxic therapyTumor recurrenceCellular reservoirsTreatment resistanceTherapeutic resistanceIncurable diseaseTumor progressionStem cellsCell proliferationPathway activationGlioblastomaα2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis
Su Y, Lau S, Ip J, Cheung K, Cheung T, Fu A, Ip N. α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 13651-13660. PMID: 31209021, PMCID: PMC6613132, DOI: 10.1073/pnas.1903891116.Peer-Reviewed Original ResearchConceptsNeural stem cell homeostasisAdult hippocampal neurogenesisNeural stem cellsIntermediate progenitor cellsRho GTPase-activating proteinNeural stem cell subpopulationsGTPase-activating proteinAdult neural stem cellsHippocampal neurogenesisSingle-cell RNA sequencingStem cell homeostasisAnxiety/depression-like behaviorsHippocampal synaptic plasticityPremature differentiation of neural stem cellsNeural stem cell poolRNA sequencingCell homeostasisPseudotime analysisGeneration of neuronsDifferentiation of neural stem cellsProduction of neuronsPremature differentiationLifelong generationBrain functionAdult neurogenesis
2009
Lnk Constrains Oncogenic JAK2-Induced Myeloproliferative Disease in Mice.
Bersenev A, Wu C, Balcerek J, Tong W. Lnk Constrains Oncogenic JAK2-Induced Myeloproliferative Disease in Mice. Blood 2009, 114: 1437. DOI: 10.1182/blood.v114.22.1437.1437.Peer-Reviewed Original ResearchOncogenic JAK2TPO stimulationHematopoietic stem cell homeostasisDownstream signal transduction pathwaysStem cell homeostasisAdaptor protein LNKSignal transduction pathwaysPhysiological negative regulatorCell surface receptorsImportant signaling axisWild-type bone marrow cellsDouble mutantTransduction pathwaysJAK2 activationHSC poolLNK deficiencyNegative regulatorJanus kinaseCell homeostasisCell developmentCytokine receptorsSignaling AxisJAK2 pathwayChromosomal translocationsMPD development
2008
Lnk Controls Hematopoietic Stem Cell Self-Renewal through Direct Interactions with JAK2 and Contributes to Oncogenic JAK2-Induced Myeloproliferative Diseases in Mice
Bersenev A, Wu C, Balcerek J, Tong W. Lnk Controls Hematopoietic Stem Cell Self-Renewal through Direct Interactions with JAK2 and Contributes to Oncogenic JAK2-Induced Myeloproliferative Diseases in Mice. Blood 2008, 112: 895. DOI: 10.1182/blood.v112.11.895.895.Peer-Reviewed Original ResearchOncogenic JAK2TPO stimulationHematopoietic stem cell homeostasisStem Cell Self-RenewalHematopoietic Stem Cell Self-RenewalDownstream signal transduction pathwaysStem cell homeostasisPhosphorylated tyrosine residuesAdaptor protein LNKCell Self-RenewalSignal transduction pathwaysPhysiological negative regulatorCell surface receptorsImportant signaling axisWild-type HSCsTransduction pathwaysGenetic evidenceJAK2 activationSelf-RenewalBiochemical experimentsLNK deficiencyNegative regulatorHSC poolHSC quiescenceJanus kinase
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