2015
Lung Cancer Stem Cells
Woodard G, Jablons D. Lung Cancer Stem Cells. 2015, 199-225. DOI: 10.1007/978-3-319-21030-8_8.Peer-Reviewed Original ResearchLung cancer stem cellsCancer stem cellsLung cancerTherapeutic targetSmall cell lung cancerStem cellsCancer stem cell markersSquamous cell cancerCell lung cancerMultiple new drugsPromising therapeutic targetImportant therapeutic targetCell of originCancer stem cell hypothesisStem cell markersTumor resurgenceRecurrent diseaseCell cancerCancer mortalityClinical trialsNovel therapiesNew therapiesHigh proliferative capacitySmall molecule inhibitorsStem cell hypothesis
2013
Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma
Kaur N, Chettiar S, Rathod S, Rath P, Muzumdar D, Shaikh M, Shiras A. Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma. Molecular And Cellular Neuroscience 2013, 54: 44-57. PMID: 23337036, DOI: 10.1016/j.mcn.2013.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationCell Transformation, NeoplasticDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGene SilencingGlioblastomaHumansMiceMice, Inbred NODMice, SCIDNeoplastic Stem CellsTranscription, GeneticWnt Signaling PathwayWnt1 ProteinWnt3A ProteinConceptsWnt/β-cateninDevelopmental signaling pathwaysTumor progressionΒ-cateninCancer stem cell hypothesisRole of Wnt3aStem cell hypothesisIntra-cranial tumoursStem-like cellsNovel therapeutic strategiesGlioma stemPromotes Tumor ProgressionSignaling pathwaysCell migrationDistinct populationsCell hypothesisGlioma tumorigenesisCell proliferationWnt3aTherapeutic strategiesMalignant transformationTumor developmentPathwayWntGlioma cells
2010
Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells
Reddy E, Chettiar S, Kaur N, Ganeshkumar R, Shepal V, Shanbhag N, Shiras A. Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells. Cancer Gene Therapy 2010, 18: 206-218. PMID: 21109781, DOI: 10.1038/cgt.2010.71.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementCell ProliferationCyclin-Dependent Kinase Inhibitor p21Down-RegulationFemaleGene Expression Regulation, NeoplasticGliomaHumansMatrix Metalloproteinase 2Melanoma-Specific AntigensMiceMice, SCIDNeoplastic Stem CellsNerve Tissue ProteinsOncogene ProteinsSignal TransductionXenograft Model Antitumor AssaysConceptsGlioma stem cellsStem cellsBrain tumor stem cellsCancer-initiating stem cellsHigh-grade gliomasEffective therapeutic targetingAnti-proliferative effectsGlioma cell invasionMelanoma antigen gene (MAGE) familyCancer stem cell hypothesisInhibits cell proliferationTumor stem cellsCell cycle arrest proteinsInducers of differentiationMMP-9Brain tumorsStem cell hypothesisMMP-2Therapeutic targetingAnti-proliferative functionDlxin-1MAGE familyHNGC-2 cellsCell invasionCell proliferation
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