Characterization of Vixotrigine, a Broad-Spectrum Voltage-Gated Sodium Channel Blocker
Hinckley C, Kuryshev Y, Sers A, Barre A, Buisson B, Naik H, Hajos M. Characterization of Vixotrigine, a Broad-Spectrum Voltage-Gated Sodium Channel Blocker. Molecular Pharmacology 2021, 99: 49-59. PMID: 33298520, DOI: 10.1124/molpharm.120.000079.Peer-Reviewed Original ResearchConceptsNav blockersNav subtypesVoltage-gated sodium channel subtypesSodium channelsSteady-state inactivation curveSodium channel blockersSodium channel subtypesUse-dependent mannerState-dependent inhibitionVoltage-gated sodium channelsState-dependent blockNeuropathic painAntiepileptic therapyProlong recoveryChannel blockersSensory neuronsChannel subtypesSodium currentBlockersVixotrigineNeural typeSubtypesHigh potencyRecombinant systemsPain
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