Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist
Bai G, Yang Y, Shi Q, Liu Z, Zhang Q, Zhu Y. Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist. Acta Pharmacologica Sinica 2008, 29: 1187-1194. PMID: 18817623, DOI: 10.1111/j.1745-7254.2008.00859.x.Peer-Reviewed Original ResearchConceptsRadix Aconiti Lateralis PreparataChinese hamster ovaryAdenosine monophosphateBeta2-adrenergic receptor agonistExperimental asthma modelPeriod of asthmaCyclic adenosine monophosphateBeta2-adrenergic receptorStructure-activity relationshipB2-ARGreen fluorescent protein reporter geneReceptor agonistsFluorescent protein reporter geneIn vivo studiesAsthma modelHigh-performance liquid chromatographic fractionsLiquid chromatographic fractionationAgonistsGuinea pigsMass spectrometryReporter geneHamster ovaryBioactivity-directed fractionationActive compoundsCompounds
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