2020
AP-1 controls the p11-dependent antidepressant response
Chottekalapanda R, Kalik S, Gresack J, Ayala A, Gao M, Wang W, Meller S, Aly A, Schaefer A, Greengard P. AP-1 controls the p11-dependent antidepressant response. Molecular Psychiatry 2020, 25: 1364-1381. PMID: 32439846, PMCID: PMC7303013, DOI: 10.1038/s41380-020-0767-8.Peer-Reviewed Original ResearchConceptsAP-1 functionSelective serotonin reuptake inhibitorsTranscriptional programsSpecific gene expression programsActivator protein-1 complexGene expression programsAntidepressant responseProtein-1 complexExpression programsMolecular networksC-JunAP-1PI3KExtracellular serotonin levelsSerotonin reuptake inhibitorsC-fosPrecise modeNeuronal plasticitySSRI actionAntidepressant effectsReuptake inhibitorsSSRI responseSerotonin levelsPrescribed drugsTherapeutic effect
2019
Spatial genome exploration in the context of cognitive and neurological disease
Rajarajan P, Borrman T, Liao W, Espeso-Gil S, Chandrasekaran S, Jiang Y, Weng Z, Brennand KJ, Akbarian S. Spatial genome exploration in the context of cognitive and neurological disease. Current Opinion In Neurobiology 2019, 59: 112-119. PMID: 31255842, PMCID: PMC6889018, DOI: 10.1016/j.conb.2019.05.007.Peer-Reviewed Original ResearchConceptsGenome explorationSpecific gene expression programsImportant regulatory layerTopological chromatin domainsGene expression programsChromosomal contact mapsChromatin domainsGenome organizationExpression programsRegulatory layerTranscriptional regulationChromosomal contactsWidespread remodelingTranscriptomic analysisRepeat sequencesUnexpected linkNeuronal lineageNeural differentiationNon-contiguous sequencesContact mapsAbnormal expansionNeurodegenerative diseasesNew insightsSequenceMouse brain
2016
MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis
Roden C, Lu J. MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis. Current Stem Cell Reports 2016, 2: 183-196. PMID: 27547713, PMCID: PMC4988405, DOI: 10.1007/s40778-016-0057-1.Peer-Reviewed Original ResearchHematopoietic stem cellsStem cellsPost-transcriptional gene regulation mechanismSpecific gene expression programsPost-transcriptional gene expressionSmall non-coding RNAsGene expression programsLeukemia stem cellsGene regulation mechanismsFunction of miRNAsNon-coding RNAsStudy of miRNAsRole of miRNAsCell signaling pathwaysLSC biologyCancer stem cell conceptStem cell fieldEpigenetic machineryExpression programsHSC emergenceEpigenetic programsStem cell conceptEpigenetic regulatorsDifferentiated progenyHSC niche
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