2024
DNA methylation in mammalian development and disease
Smith Z, Hetzel S, Meissner A. DNA methylation in mammalian development and disease. Nature Reviews Genetics 2024, 26: 7-30. PMID: 39134824, DOI: 10.1038/s41576-024-00760-8.Peer-Reviewed Original ResearchLong-read sequencing technologiesDNA methylation fieldDNA methylation landscapeGenome functionMethylation landscapeSequencing technologiesEpigenetic codeGenomic characterizationRegulatory layerDNA methylationCell physiologyMammalian developmentMammalian lifespanGenetic featuresFunctional understandingSingle-cellDNAMechanistic discoveriesSomatic transitionsPhases of discoveryDevelopmental potentialDiscoveryPhenotypeSenescencePhysiology
2019
Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells
Albert AE, Adua SJ, Cai WL, Arnal-Estapé A, Cline GW, Liu Z, Zhao M, Cao PD, Mariappan M, Nguyen DX. Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells. Molecular Cancer Research 2019, 17: 2343-2355. PMID: 31551255, PMCID: PMC6938689, DOI: 10.1158/1541-7786.mcr-19-0245.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 4Adenocarcinoma of LungAmino AcidsCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCell Line, TumorCell ProliferationCyclin B1Eukaryotic Initiation Factor-2Gene Expression Regulation, NeoplasticHumansNF-E2-Related Factor 2Oxidative StressPhosphatidylinositol 3-KinasesProtein BiosynthesisProteostasisSignal TransductionStress, PhysiologicalTOR Serine-Threonine KinasesConceptsIntegrated stress responseProtein translationCell cycle progressionLung adenocarcinoma cellsLung cancer cellsNew regulatory layerCertain oncogenic mutationsAmino acid limitationNovel regulatory mechanismControl of proteostasisCancer cellsDifferent biological consequencesEIF2α-dependent mannerAmino acid metabolismAdenocarcinoma cellsNrf2 protein levelsPI3K pathwayConserved pathwayRegulatory layerISR pathwayATF4 branchCell cycle regulator cyclin B1MTOR/PI3K pathwaySelect proteinsAsparagine synthetaseSpatial genome exploration in the context of cognitive and neurological disease
Rajarajan P, Borrman T, Liao W, Espeso-Gil S, Chandrasekaran S, Jiang Y, Weng Z, Brennand KJ, Akbarian S. Spatial genome exploration in the context of cognitive and neurological disease. Current Opinion In Neurobiology 2019, 59: 112-119. PMID: 31255842, PMCID: PMC6889018, DOI: 10.1016/j.conb.2019.05.007.Peer-Reviewed Original ResearchConceptsGenome explorationSpecific gene expression programsImportant regulatory layerTopological chromatin domainsGene expression programsChromosomal contact mapsChromatin domainsGenome organizationExpression programsRegulatory layerTranscriptional regulationChromosomal contactsWidespread remodelingTranscriptomic analysisRepeat sequencesUnexpected linkNeuronal lineageNeural differentiationNon-contiguous sequencesContact mapsAbnormal expansionNeurodegenerative diseasesNew insightsSequenceMouse brain
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