Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies
Mehnert JM, Kluger HM. Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies. Current Oncology Reports 2012, 14: 449-457. PMID: 22723080, PMCID: PMC4447200, DOI: 10.1007/s11912-012-0249-5.Peer-Reviewed Original ResearchConceptsDriver mutationsSpecific patient subsetsPotential therapeutic strategyPatient subsetsSomatic driver mutationsMetastatic melanomaBedside studiesUveal melanomaTherapeutic strategiesBRAFV600E mutationMalignant transformationMelanomaMolecular classificationDevelopment of inhibitorsHuman samplesMutationsMolecular biologyBRAFDiseaseDiagnosis of Intussusception by Physician Novice Sonographers in the Emergency Department
Riera A, Hsiao AL, Langhan ML, Goodman TR, Chen L. Diagnosis of Intussusception by Physician Novice Sonographers in the Emergency Department. Annals Of Emergency Medicine 2012, 60: 264-268. PMID: 22424652, PMCID: PMC3431911, DOI: 10.1016/j.annemergmed.2012.02.007.Peer-Reviewed Original ResearchConceptsPediatric emergency physiciansIleocolic intussusceptionEmergency physiciansUltrasonographic resultsUrban tertiary care children's hospitalPredictive valueBedside emergency department ultrasonographyTertiary care children's hospitalEmergency department ultrasonographyDiagnosis of intussusceptionProspective convenience sample studyLikelihood ratioNegative predictive valuePositive predictive valueConvenience sample studyBowel ultrasonographyMedian agePediatric EDChildren's HospitalUltrasonographic studyEmergency departmentObservational studyPhysician sonographersBedside studiesIntussusception
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